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Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : Tamoxifen*/TAMDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: human breast cancer cell lines MCF-7, ZR75, T47D Results: Green tea increased the inhibitory effect of tamoxifen on the proliferation of the ER (estrogen receptor)-pos. MCF-7, 2R75, T47D human breast cancer cells in vitro. This combination regimen was also more potent than either agent alone at increasing cell apoptosis.Note : Data incomplete
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : Tamoxifen*/TAMDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: mouse xenograft model Results: Mice treated with both green tea and tamoxifen had the smallest MCF-7 xenograft tumor size, and the highest levels of apoptosis in tumor tissue, as compared with either agent administered alone. moreover, the suppression of angiogenesis in vivo correlated with larger areas of necrosis and lower tumor blood vessel density in treated xenografts. The combination of green tea and tamoxifen significantly reduced the levels of estrogen receptor (ER)-alpha, in comparison to either agent alone.Note : Data incomplete
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : (-)epigallocatechin-3-gallate (EGCG)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 10-40 micromolar/LDuration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : NS-398Dose/Conc.(drug) : 10 micromolar/LResult : PositiveRemark : Type of experiment: human prostate cancer cells LNCaP, PC-3, and CWR22Rn1 Results: Combination of EGCG and NS-398 resulted in enhanced (a) cell growth inhibition; (b) apoptosis induction; (c) expression of Bax, pro-caspase-6, and pro-caspase-9, and poly (ADP) ribose polymerase cleavage; (d) inhibition of peroxisome proliferator activated receptor g; and (e) inhibition of nuclear factor-kB compared with the additive effects of the two agents alone, suggesting a possible synergism.Note : Data incomplete
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : green tea polyphenolsType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 0.1% in drinking waterDuration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : CelecoxibDose/Conc.(drug) : 5 mg/kg, i.p., daily, 5 days per weeksResult : PositiveRemark : Type of animal: nude mice Results: Combination treatment with green tea polyphenols and celecoxib resulted in enhanced (a) tumor growth inhibition, (b) lowering of prostate-specific antigen levels, (c) lowering of insulin-like growth factor-l levels, and (d) circulating levels of serum insulin-like growth factor binding protein-3 compared with results of single-agent treatment.Note : Data incomplete
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : green tea catechins (GTC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1 GTCDuration : 42 weeksType of interaction : P.Kinetics & P.DynamicsInteraction with drug : Sodium nitriteDose/Conc.(drug) : 0.2%Result : PositiveRemark : Combined treatment with green tea catechins and sodium nitrite selectively promotes rat forestomach carcinogenesis after initiation with N-methyl-N'-nitro-nitrosoguanidine.Note : Type of experiment: male rats were given 0.01% N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in their drinking water and 5% NaCl in the diet for 10 wk for glandular stomach initiation and a single intragastric administration of 100 mg/kg/bodyweight of MNNG at week 9 for forestomach initiation. From week 11, they received either drinking water contg. 0.2% sodium nitrite (NaNO2) and a diet supplemented with 1% GTC in combination, each individual chem. alone or a basal diet until the end of week 42. Data incomplete
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : tea-polyphenolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1.2 mg/mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : Ascorbic acid*/Vitamin CDose/Conc.(drug) : 0.08 mg/mLResult : PositiveRemark : The inhibitive effect of the mixed solution of tea-polyphenol and vitamin C is more effcient than that of individuals, sep. The strongest inhibition is 98.23% when the concentration of mixture is tea-polyphenol 1.2 mg/mL, vitamin C 0.08 mg/mL.Note : Data incomplete
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : epigallocatechin-3-gallateType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : -Result : PositiveRemark : Epigallocatechin-3-gallate showed synergy with 5-fluorouracil in human colon carcinoma cell line.Note : Data incomplete
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : Green teaType of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : MaleAge : 44 yearsRoute : Oral administrationDose/Conc.(herb) : One-half to one gallon per dayDuration : One weekType of interaction : PharmacodynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : The patient had an international normalized ratio (INR) 3.79 after receiving warfarin on entering clinic. Twenty-two days later his INR was 1.367. One month later the patient's INR was 1.14. It was subsequently discovered that the patient began drinking one-half to one gallon per day about one week prior to the INR 1.37. On discontinuation of green tea, the patient's INR increased to 2.55.Note : Data incomplete.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : vitamin KType of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1 (M/F=1/-)N(Treatment) : 1 (M/F=1/-)Sex : MaleAge : 44 years oldRoute : Oral administrationDose/Conc.(herb) : one-half to one gallon of green tea per dayDuration : one weekType of interaction : PharmacodynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : -The patient was receiving warfarin for thromboembolic prophylaxis. The patient had an international normalized ratio (INR) of 3.79 on entering our clinic. Twenty-two days later his INR was 1.37. One month later the patient's INR was 1.14. It was subsequently discovered that the patient began drinking one-half to one gallon of green tea per day about one week prior to the INR of 1.37. On discontinuation of the green tea, the patient's INR increase to 2.55. - Green tea can be a significant source of vitamin K and thus antagonize the effect of warfarin.Note : Data incomplete
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : EGCG (-)-epigallocatechin-3-gallateType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : ErlotinibDose/Conc.(drug) : -Result : PositiveRemark : In vitro studies with 5 head and neck cancer cell lines revealed that synergistic cell growth inhibition by the combination of EGCG and erlotinib was associated with significantly greater inhibition of pEGFR and pAKT, increased activation of caspases 9, 3 and PARP compared to the inhibition induced by EGCG or erlotinib alone.Note : Data incomplete.
