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| Thai / English name |
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : Methanol, catechin epigallocatechin gallate (EGCG)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Dose in 5.3 L**Duration : -Type of interaction : PharmacokineticsInteraction with drug : Mycophenolic acid*/Mycophenolate/MMF/MPA/MofetilDose/Conc.(drug) : 240 micromolarResult : NegativeRemark : Results: data points did not fit the IC50 curve.Note : Type of experiment: *Human liver microsomal (HLM) **Working solutions were freshly prepared so that final herbal concentrations in screening incubations would represent the recommended daily intake of each extract in 53, 5.3, and 0.53 liters. Each herbal extract was coincubated at three concentrations with trifluoperazine (for UGT1A4), serotonin (for UGT1A6), and mycophenolic acid (for UGT1A9) and human liver microsome. Formation of trifluoperezine glucoronide, serotonin glucuronide, and mycophenolic acid beta-D- glucoronide were used as index reactions for activity of UGT1A4, UGT1A6, and UGT1A9 enzyme activities, respectively.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : Methanol, catechin epigallocatechin gallate (EGCG)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Dose in 0.53 L**Duration : -Type of interaction : PharmacokineticsInteraction with drug : Mycophenolic acid*/Mycophenolate/MMF/MPA/MofetilDose/Conc.(drug) : 240 micromolarResult : NegativeRemark : Results: data points did not fit the IC50 curve.Note : Type of experiment: *Human liver microsomal (HLM) **Working solutions were freshly prepared so that final herbal concentrations in screening incubations would represent the recommended daily intake of each extract in 53, 5.3, and 0.53 liters. Each herbal extract was coincubated at three concentrations with trifluoperazine (for UGT1A4), serotonin (for UGT1A6), and mycophenolic acid (for UGT1A9) and human liver microsome. Formation of trifluoperezine glucoronide, serotonin glucuronide, and mycophenolic acid beta-D- glucoronide were used as index reactions for activity of UGT1A4, UGT1A6, and UGT1A9 enzyme activities, respectively.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 250N(Treatment) : 126Sex : Both sexAge : 69+/-10 yrs.Route : Oral administrationDose/Conc.(herb) : Consumption of herbs at least 4 times per weekDuration : -Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : Consumption of herbs at least 4 times per week was associated with suboptimal anticoagulation control with warfarin. Patients treated with warfarin should not only be aware of the intake of herbal drugs but also of foods with herbal ingredients such as garlic, ginger, and papaya.Note : Patients with atrial fibrillation (AF) who were prescribed warfarin therapy for at least 6 months before the study were recruited from the medical and cardiac clinics.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : Epigallocatechin gallate (EGCG)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Doxorubicin*/Adrimycin/ADR/AdriaDose/Conc.(drug) : -Result : PositiveRemark : EGCG exerts reversal effect on MDR through modulation of p-glycoprotein transport activity rather than inhibition of p-glycoprotein expression.Note : Data from review
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : decaffeinated green teaType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 11N(Treatment) : 11Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 4 DGT capsules/day (DGT capsule contained 211+/-25 mg of green tea catechins and <1 mg of caffeine)Duration : 14 daysType of interaction : PharmacokineticsInteraction with drug : AlprazolamDose/Conc.(drug) : 2 mgResult : NegativeRemark : There were no significant differences in ALPZ pharmacokinetics at baseline and after DGT treatment (all P values >/=0.05; max. concn. in plasma, 33+/-8 vs. 34+/-13 ng/mL; time to reach max. concn. in plasma, 1.4+/-1.2 vs. 1.4+/-1.2 h; area under the plasma concn. vs. time curve, 480+/-119 vs. 510 +/- 107 h-ng-ml-1; half-life of elimination, 12.3+/-1.7 vs. 13.1+/-3.4 h).Note : Data incomplete Subject total: healthy volunteers - Results indicate that DGT is unlikely to alter the disposition of medications primarity dependent on the CYP2D6 or CYP3A4 pathways of metabolism. Abbreviation decaffeinated green tea : DGT dextromethorphan metabolic ratios: DMRS alprazola: ALPZ
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : 1 weeksType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : Although single treatments with green tea exts. or grape seed ext. had negligible effects, 1 wk of treatment with them resulted in a significant increase in the ke of i.v. administered midazolam (MDZ), indicating the induction of CYP3A in the liver.Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : black tea (2.5% w/v)Duration : 1 dayType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Black tea treatment induced hepatic CYP1A2 activity and expression.Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : black tea (2.5% w/v)Duration : 1 monthType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Black tea treatment induced hepatic CYP1A2 activity and expression.Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : catechinsType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.25% catechinDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The contents of cytochrome P450 contents in catechin free diet (MW-0C) group was increased to 95%, compared with normal group. 0.25% catechin (MW-0.25C) and 0.5% catechin (MW-0.5C) groups were reduced to 16% and 31%, resp., compared with MW-0C group.Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : catechinsType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.5% catechinDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The contents of cytochrome P450 contents in catechin free diet (MW-0C) group was increased to 95%, compared with normal group. 0.25% catechin (MW-0.25C) and 0.5% catechin (MW-0.5C) groups were reduced to 16% and 31%, resp., compared with MW-0C group.Note : Data incomplete
