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Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : (-)-epigallocatechin-3-gallate (EGCG)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 150 mg/kgDuration : 30 min.*Type of interaction : PharmacokineticsInteraction with drug : Nadolol*/CorgardDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : - Pretreatment with GTE resulted in marked reductions in the maximum concentration (Cmax) and area under the time-plasma concentration curve (AUC) of nadolol by 85% and 74%, respectively, as compared with control. In addition, EGCG alone significantly reduced Cmax and AUC of nadolol. Amounts of nadolol excreted into the urine were decreased by pretreatments with GTE and EGCG, while the terminal half-life on nadolol was not different among groups.Note : Duration: *Rats received green tea extract (GTE) and (-)-epigallocatechin-3-gallate (EGCG) or saline (control) by oral gavage, 30 min before a single intragastric administratiion of nadolol. - These results suggest that the coadministration with green tea catechins, particularly EGCG, causes a significant alteration in the pharmacokinetics of nadolol.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : green tea extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 25 microgram/mlDuration : 5 minutesType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : - Details of the standardized Green tea extracts: 99.61% Tea polyphenols, 65.38% EGCG, 82.79% Catechins, 1.17% Caffeine, 3.98% Water, 0.18% Sulfated ash. - Results: The degree of CYP3A4 inhibition of Ginkgo biloba was 93.8% and IC50 values of that inhibit CYP3A4-mediated metabolism of midazolam = 9.96 microgram/ml, 95% Cl: 5.41-18.3.Note : The effects of complementary and alternative medicine (CAM) on CYP3A4-mediated metabolism of midazolam and docetaxel were determined in human liver microsomes (HLM), using liquid-chromatography coupled to tandem mass spectrometry (LC-MS/MS).
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : green tea extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 microgram/mlDuration : 30 minutesType of interaction : PharmacokineticsInteraction with drug : Docetaxel*/TaxotereDose/Conc.(drug) : -Result : PositiveRemark : - Details of the standardized Green tea extract: 99.61% Tea polyphenols, 65.38% EGCG, 82.79% Catechins, 1.17% Caffeine, 3.98% Water, 0.18% Sulfated ash. - Results: The degree of CYP3A4 inhibition of Ginkgo biloba was 90.9% and IC50 values of that inhibit CYP3A4-mediated metabolism of docetaxel = 42.3 microgram/ml, 95% Cl: 36.2-49.4.Note : The effects of complementary and alternative medicine (CAM) on CYP3A4-mediated metabolism of midazolam and docetaxel were determined in human liver microsomes (HLM), using liquid-chromatography coupled to tandem mass spectrometry (LC-MS/MS).
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : EGCGType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 15 micromolar/nMDuration : 24 h.Type of interaction : PharmacodynamicsInteraction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosineDose/Conc.(drug) : 5 micromolar/nMResult : PositiveRemark : - Cell number (% of control) 81.3 - Combination index 1.328 - Six out of nine combinations applied yielded additive effects.Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : EGCGType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 15 micromolar/nMDuration : 24 h.Type of interaction : PharmacodynamicsInteraction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosineDose/Conc.(drug) : 10 micromolar/nMResult : PositiveRemark : - Cell number (% of control) 73.6 - Combination index 1.319 - Six out of nine combinationsNote : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : EGCGType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 15 micromolar/nMDuration : 24 h.Type of interaction : PharmacodynamicsInteraction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosineDose/Conc.(drug) : 20 micromolar/nMResult : PositiveRemark : - Cell number (% of control) 58.7 - Combination index 1.136 - Six out of nine combinations applied yielded additive effects.Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : EGCGType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 20 micromolar/nMDuration : 24 h.Type of interaction : PharmacodynamicsInteraction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosineDose/Conc.(drug) : 5 micromolar/nMResult : PositiveRemark : - Cell number (% of control) 55.9 - Combination index 1.030 (Additive combination effect) - Six out of nine combinations applied yielded additive effects.Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : EGCGType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 20 micromolar/nMDuration : 24 h.Type of interaction : PharmacodynamicsInteraction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosineDose/Conc.(drug) : 10 micromolar/nMResult : PositiveRemark : - Cell number (% of control) 53.0 - Combination index 1.078 (Additive combination effect) - Six out of nine combinations applied yielded additive effects.Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : EGCGType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 20 micromolar/nMDuration : 24 h.Type of interaction : PharmacodynamicsInteraction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosineDose/Conc.(drug) : 20 micromolar/nMResult : PositiveRemark : - Cell number (% of control) 39.7 - Combination index 1.004 (Additive combination effect) - Six out of nine combinations applied yielded additive effects.Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : EGCGType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 25 micromolar/nMDuration : 24 h.Type of interaction : PharmacodynamicsInteraction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosineDose/Conc.(drug) : 5 micromolar/nMResult : PositiveRemark : - Cell number (% of control) 15.8 - Combination index 0.941 (Additive combination effect) - Six out of nine combinations applied yielded additive effects.Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC
