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THEACEAE Camellia sinensis (L.) Kuntze

Synonym

THEACEAE Thea sinensis L.
THEACEAE Camellia sinensis (L.) Kuntze var. assamica (Mast.) Kitam.

Thai / English name

ชา*

[28-32] of 33 article(s) found

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[28] SYNERGISTIC INHIBITION OF HEAD AND NECK TUMOR GROWTH BY GREEN TEA (-)-EPIGALLOCATECHIN-3-GALLATE AND EGFR TYROSINE KINASE INHIBITOR.
ZHANG X,ZHANG H,TIGHIOUART M,ET AL.
INT J CANCER 2008 Vol.123(5),1005-14 420241 [Abstract]

Part Used : ใบ
Activity : DRUG INTERACTION

Solvent/Active Compound : EGCG (-)-epigallocatechin-3-gallate

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : -

Duration : The combination of EGCG and erlotinib was orally gavaged at the same doses for 7 days, followed by s.c. injection with Tu212 cells. Animals were continuously administered the agents 5 days weekly for 7 wk.
Type of interaction : Pharmacodynamics

Interaction with drug : Erlotinib
Dose/Conc.(drug) : -

Result : Positive

Remark : The combined treatment resulted in significantly greater inhibition of tumor growth and delayed tumor progression as a result of increased apoptosis, decreased cell proliferation and reduced pEGFR and pAKT compared to the single agent treatment groups.

Note : Data incomplete.

[29] SYNERGISTIC INHIBITION OF LUNG TUMORIGENESIS BY A COMBINATION OF GREEN TEA POLYPHENOLS AND ATORVASTATIN.
LU G,XIAO H,YOU H,ET AL.
CLIN CANCER RES 2008 Vol.14(15),4981-8 435126 [Abstract]

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : Polyphenon E (PPE)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Atorvastatin
Dose/Conc.(drug) : -

Result : Positive

Remark : Treatment with combination of PPE and atorvastatin also synergistically decreased the number of viable H1299 and H460 cell. The combination of PPE and atrovastatin was more efficient in reducing the antiapoptotic protein Mcl-1 level and increasing the cleaved caspase-3 and cleaved poly(ADP)-ribose polymerase level than single agent.

Note : Data incomplete.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : Polyphenon E (PPE)

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 0.25% in drinking fluid

Duration : 16 weeks
Type of interaction : Pharmacodynamics

Interaction with drug : Atorvastatin
Dose/Conc.(drug) : 200 ppm in diet

Result : Positive

Remark : The low-dose combinations of PPE and atrovastatin significantly reduced both tumor multiplicity and tumor burden by 56% and 55%, respectively. However the individual agent, PPE or atorvastatin, were not effective inhibiting lung tumorigenesis in tumorigenesis model.

Note : Data incomplete.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : Polyphenon E (PPE)

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 0.5% in drinking fluid

Duration : 16 weeks
Type of interaction : Pharmacodynamics

Interaction with drug : Atorvastatin
Dose/Conc.(drug) : 400 ppm in diet

Result : Positive

Remark : The low-dose combinations of PPE and atrovastatin significantly reduced both tumor multiplicity and tumor burden by 56% and 55%, respectively. However the individual agent, PPE or atorvastatin, were not effective inhibiting lung tumorigenesis in tumorigenesis model.

Note : Data incomplete.

[30] SYNERGISTIC EFFECT OF GREEN TEA POLYPHENOLS ON THEIR PROTECTION AGAINST FK506-INDUCED CYTOTOXICITY IN RENAL CELLS.
HISAMURA F,KOJIMA-YUASA A,HUANG X,ET AL.
AM J CHIN MED 2008 Vol.36(3),615-24 435127 [Abstract]

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : epigallocatechin-gallate (EGCG), (+)-catechin (C), (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin-gallate (ECG)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Tacrolimus
Dose/Conc.(drug) : -

Result : Positive

Remark : The combined treatment with 5 micromolar EGCG and 5 micromolar of C, EC, EGC or ECG reduced FK506 (tacrolimus)-induced cytotoxicity in LLC-PK1. Similarty, the combined treatment with 5 micromolar EGC and 5 micromolar of C, EC, EGCG or ECG also reduced the cytotoxicity.

Note : Data incomplete

[31] INHIBITORY EFFECT OF TEA POLYPHENOLS IN COMBINATION WITH ANTI-TUMOR DRUGS ON CELL PROLIFERATION OF THE MULTIRESISTANT HNE-1 CELL LINE.
WANG C,CHEN H,YE L,ET AL.
ZHONGGUO YAOFANG 2009 Vol.20(1),33-5 457025 [Abstract]

Part Used : ใบ
Activity : DRUG INTERACTION

Solvent/Active Compound : Tea polyphenols

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0.5 mg/mL

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Vincristine*/VCR/LCR/Leurocristine
Dose/Conc.(drug) : -

Result : Positive

Remark : When the anti-tumor drugs (vincristine, pingyangmycin, 5-Fu, cisplatin) were used in combination with tea polyphenols (0.50 mg/mL) as compared without, the inhibition ratio on HNE-1 (200) cell line was increased by 100-300%.

Note : Data incomplete.

Part Used : ใบ
Activity : DRUG INTERACTION

Solvent/Active Compound : Tea polyphenols

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0.5 mg/mL

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Pingyangmycin*/Bleomycetin/Bleomycin A5
Dose/Conc.(drug) : -

Result : Positive

Remark : When the anti-tumor drugs (vincristine, pingyangmycin, 5-Fu, cisplatin) were used in combination with tea polyphenols (0.50 mg/mL) as compared without, the inhibition ratio on HNE-1 (200) cell line was increased by 100-300%.

Note : Data incomplete.

Part Used : ใบ
Activity : DRUG INTERACTION

Solvent/Active Compound : Tea polyphenols

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0.5 mg/mL

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FU
Dose/Conc.(drug) : -

Result : Positive

Remark : When the anti-tumor drugs (vincristine, pingyangmycin, 5-Fu, cisplatin) were used in combination with tea polyphenols (0.50 mg/mL) as compared without, the inhibition ratio on HNE-1 (200) cell line was increased by 100-300%.

Note : Data incomplete.

Part Used : ใบ
Activity : DRUG INTERACTION

Solvent/Active Compound : Tea polyphenols

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0.5 mg/mL

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Cisplatin*/CDDP
Dose/Conc.(drug) : -

Result : Positive

Remark : When the anti-tumor drugs (vincristine, pingyangmycin, 5-Fu, cisplatin) were used in combination with tea polyphenols (0.50 mg/mL) as compared without, the inhibition ratio on HNE-1 (200) cell line was increased by 100-300%.

Note : Data incomplete.

[32] ANTIBACTERIAL ACTIVITY OF GREEN TEA AND ITS EXTRACTS AGAINST MRSA.
HUA D,PENG Q,ZENG X,ET AL.
ZHONGGUO KANGSHENGSU ZAZHI 2010 Vol.35(3),228-33 478856 [Abstract]

Part Used : ใบ
Activity : DRUG INTERACTION

Solvent/Active Compound : green tea leachate

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Penicillin
Dose/Conc.(drug) : -

Result : Positive

Remark : Inhibition zones of penicillin, oxacillin, ampicillin, ceftazidime, ceftezole, minocycline and tetracycline in combination with green tea leachate against MRSA were obviously larger than the single antibiotics.

Note : Data incomplete

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