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Part Used : ไม่ระบุActivity : CYP3A4 INHIBITIONSolvent/Active Compound : decaffeinated green teaType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 11N(Treatment) : 11Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 4 DGT capsules/day (DGT capsule contained 211+/-25 mg of green tea catechins and <1 mg of caffeine)Duration : 14 daysType of interaction : PharmacokineticsInteraction with drug : AlprazolamDose/Conc.(drug) : 2 mgResult : NegativeRemark : There were no significant differences in ALPZ pharmacokinetics at baseline and after DGT treatment (all P values >/=0.05; max. concn. in plasma, 33+/-8 vs. 34+/-13 ng/mL; time to reach max. concn. in plasma, 1.4+/-1.2 vs. 1.4+/-1.2 h; area under the plasma concn. vs. time curve, 480+/-119 vs. 510 +/- 107 h-ng-ml-1; half-life of elimination, 12.3+/-1.7 vs. 13.1+/-3.4 h).Note : Data incomplete Subject total: healthy volunteers - Results indicate that DGT is unlikely to alter the disposition of medications primarity dependent on the CYP2D6 or CYP3A4 pathways of metabolism. Abbreviation decaffeinated green tea : DGT dextromethorphan metabolic ratios: DMRS alprazola: ALPZ
Part Used : ไม่ระบุActivity : CYP3A4 INHIBITIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : 1 weeksType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : 1 wk of treatment with green tea ext, but not grape seed ext. caused a significant increase in the Cmax and AUCO-infinity of orally administered midazolam (MDZ) without change in the t1/2, suggesting a redn. in CYP3A activity in the small intestines.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYP3A4 INHIBITIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : 1 weeksType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : Strong inhition of these CYP activities was found by the addn. of green tea ext. or grape seed ext. in vitro.Note : Data incomplete
Part Used : -Activity : CYP3A4 INHIBITIONSolvent/Active Compound : green tea catechins, epigallocatechin gallate (EGCG)Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 42N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 800 mg epigallocatechin gallate (EGCG) dailyDuration : 4 weeksType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Four weeks of green tea catechin intervention did not alter the phenotypic indexes of CYP1A2, CYP2D6, and CYP2C9, but resulted in a 20% increase (P=0.01) in the area under the plasma buspirone concn.-time profile, suggesting a small reduction in CYP3A4 activity.Note : Subjects: healthy volunteers received a cocktail of CYP metabolic probe drugs, including caffeine, dextromethorphan, losartan, and buspirone for assessing the activity of CYP1A2, CYP2D6, CYP2C9, and CYP3A4, resp. Following the baseline evaluation, study participants underwent 4 weeks of green tea catechin intervention at a dose that contains 800 mg epigallocatechin gallate (EGCG) daily. Data incomplete
Part Used : ใบActivity : CYP3A4 INHIBITIONSolvent/Active Compound : methanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: human liver microsomes Results: Green tea extract (GTE) produced the most pronounced inhibition of CYP3A4, which ranged from 5.6% by Nature's resource to 89.9% by Natrol GTE product.Note : Data incomplete
