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THEACEAE Camellia sinensis (L.) Kuntze

Synonym

THEACEAE Thea sinensis L.
THEACEAE Camellia sinensis (L.) Kuntze var. assamica (Mast.) Kitam.

Thai / English name

ชา*

[7-12] of 12 article(s) found

หน้า 1 2

[7] EFFECTS OF REPEATED GREEN TEA CATECHIN ADMINISTRATION ON HUMAN CYTOCHROME P450 ACTIVITY.
CHOW H-H,SHERRY,HAKIM IA,ET AL.
CANCER EPIDEMIOL BIOMARKERS PREV 2006 Vol.15(12),2473-6 347694 [Abstract]

Part Used : -
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : green tea catechins, epigallocatechin gallate (EGCG)

Type of experiment : human
Type of animal : -

Type of study : non specified

N(Total) : 42
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 800 mg epigallocatechin gallate (EGCG) daily

Duration : 4 weeks
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Four weeks of green tea catechin intervention did not alter the phenotypic indexes of CYP1A2, CYP2D6, and CYP2C9, but resulted in a 20% increase (P=0.01) in the area under the plasma buspirone concn.-time profile, suggesting a small reduction in CYP3A4 activity.

Note : Subjects: healthy volunteers received a cocktail of CYP metabolic probe drugs, including caffeine, dextromethorphan, losartan, and buspirone for assessing the activity of CYP1A2, CYP2D6, CYP2C9, and CYP3A4, resp. Following the baseline evaluation, study participants underwent 4 weeks of green tea catechin intervention at a dose that contains 800 mg epigallocatechin gallate (EGCG) daily. Data incomplete

[8] INHIBITION OF HUMAN CYTOCHROME P4502E1 BY HERBAL EXTRACTS AND THEIR MAJOR ISOLATED CONSTITUENTS.
WANG Y,CORNELIOUS S,MOULICK K,ET AL.
ABSTRACTS, 56TH SOUTHEAST REGIONAL MEETING OF THE AMERICAN CHEMICAL SOCIETY, RESEARCH TRIANGLE PARK, NC, UNITED STATES, NOVEMBER 10-13 2004 Vol.(), 359726 [Abstract]

Part Used : -
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Type of experiment: human liver microsomes Results: Green tea extracts nor the catechins EGC, EGCG, ECG and EC, inhibited the activity of P 4502E1 to a significant extent.

Note : Data incomplete

[9] THE EFFECT OF FEEDING PIGLETS WITH THE DIET CONTAINING GREEN TEA EXTRACTS OR COUMARIN ON IN VITRO METABOLISM OF AFLATOXIN B1 BY THEIR TISSUES.
TULAYAKUL P,DONG KS,LI JY,ET AL.
TOXICON 2007 Vol.50(3),339-48 365828 [Abstract]

Part Used : -
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: piglets liver and intestinal tissues Results: Feeding with a diet containing green tea extracts (Sunphenon) enhances aflatoxin B1 detoxification, but the effects are noted mainly in the intestine.

Note : Data incomplete

[10] EFFECTS OF HERBAL PRODUCTS AND THEIR CONSTITUENTS ON HUMAN CYTOCHROME P4502E1 ACTIVITY.
RANER GM,CORNELIOUS S,MOULICK K,ET AL.
FOOD CHEM TOXICOL 2007 Vol.45(12),2359-65 413570 [Abstract]

Part Used : ไม่ระบุ
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : catechins

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) :

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Com. green tea prepns., along with 4 of the individual tea catechins, were also examd. and were found to have no effect on the activity P4502E1.

Note : Data incomplete

[11] CHEMOPREVENTIVE AND THERAPEUTIC MODULATION OF GREEN TEA POLYPHENOLS ON DRUG METABOLIZING ENZYMES IN 4-NITROQUINOLINE 1-OXIDE INDUCED ORAL CANCER.
SRINIVASAN P,SUCHALATHA S,BABU PVA,ET AL.
CHEM BIOL INTERACT 2008 Vol.172(3),224-34 414664 [Abstract]

Part Used : -
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : green tea polyphenols (GTP)

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 200 mg/kg

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : On supplementation of GTP by both simultaneous and post treatment mode (200 mg/kg) there was a significant increase in the activity of glutathione-S-transferase and UDP-glucuronyl transferase (Phase II enzymes) and a significant decrease in the activity of cytochrome b5, cytochrome P 450, cytochrome b5 reductase (cyt b5 R), cytochrome P 450 reductase (cyt P 450 R), aryl hydrocarbon hydroxylase (AHH), and DT-diaphorase (DTD) (Phase I enzymes).

Note : Data incomplete

[12] VARIABLE INHIBITORY EFFECT OF DIFFERENT BRANDS OF COMMERCIAL HERBAL SUPPLEMENTS ON HUMAN CYTOCHROME P-450 CYP3A4.
WANWIMOLRUK S,WONG K,WANWIMOLRUK P
DRUG METABOL DRUG INTERACT 2009 Vol.24(1),17-35 462498 [Abstract]

Part Used : ใบ
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : methanol

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: human liver microsomes Results: Green tea extract (GTE) produced the most pronounced inhibition of CYP3A4, which ranged from 5.6% by Nature's resource to 89.9% by Natrol GTE product.

Note : Data incomplete

หน้า 1 2

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