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THEACEAE Camellia sinensis (L.) Kuntze

Synonym

THEACEAE Thea sinensis L.
THEACEAE Camellia sinensis (L.) Kuntze var. assamica (Mast.) Kitam.

Thai / English name

ชา*

[1-2] of 2 article(s) found

หน้า 1 2 3

[1] EPIGALLOCATECHIN GALLATE, ELLAGIC ACID, AND ROSMARINIC ACID PERTURB DNTP POOLS AND INHIBIT DE NOVO DNA SYNTHESIS AND PROLIFERATION OF HUMAN HL-60 PROMYELOCYTIC LEUKEMIA CELLS: SYNERGISM WITH ARABINOFURANOSYLCYTOSINE.
PHILIPP SAIKO, MARIE-THERESE STEINMANN, HEIKE SCHUSTER,ET AL.
PHYTOMEDICINE 2015 Vol.22(),213-22 $54161 [Full]

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT

Solvent/Active Compound : RA

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 100 micromolar/nM

Duration : 24 h.
Type of interaction : Pharmacodynamics

Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 20 micromolar/nM

Result : Positive

Remark : - Cell number (% of control) 45.1 - Combination index 0.959 - Eight out of nine RA combinations applied showed synergism.

Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT

Solvent/Active Compound : RA

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 125 micromolar/nM

Duration : 24 h.
Type of interaction : Pharmacodynamics

Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 5 micromolar/nM

Result : Positive

Remark : - Cell number (% of control) 27.9 - Combination index 0.886 (synergistic combination effect). - Eight out of nine RA combinations applied showed synergism.

Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT

Solvent/Active Compound : RA

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 125 micromolar/nM

Duration : 24 h.
Type of interaction : Pharmacodynamics

Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 10 micromolar/nM

Result : Positive

Remark : - Cell number (% of control) 24.0 - Combination index 0.873 (synergistic combination effect). - Eight out of nine RA combinations applied showed synergism.

Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT

Solvent/Active Compound : RA

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 125 micromolar/nM

Duration : 24 h.
Type of interaction : Pharmacodynamics

Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 20 micromolar/nM

Result : Positive

Remark : - Cell number (% of control) 20.6 - Combination index 0.867 (synergistic combination effect). - Eight out of nine RA combinations applied showed synergism.

Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT

Solvent/Active Compound : RA

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 150 micromolar/nM

Duration : 24 h.
Type of interaction : Pharmacodynamics

Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 5 micromolar/nM

Result : Positive

Remark : - Cell number (% of control) 8.7 - Combination index 0.880 (synergistic combination effect). - Eight out of nine RA combinations applied showed synergism.

Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT

Solvent/Active Compound : RA

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 150 micromolar/nM

Duration : 24 h.
Type of interaction : Pharmacodynamics

Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 10 micromolar/nM

Result : Positive

Remark : - Cell number (% of control) 8.8 - Combination index 0.884 (synergistic combination effect). - Eight out of nine RA combinations applied showed synergism.

Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT

Solvent/Active Compound : RA

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 150 micromolar/nM

Duration : 24 h.
Type of interaction : Pharmacodynamics

Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 20 micromolar/nM

Result : Positive

Remark : - Cell number (% of control) 8.9 - Combination index 0.890 (synergistic combination effect). - Eight out of nine RA combinations applied showed synergism.

Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

[2] COMBINED INHIBITORY EFFECTS OF GREEN TEA POLYPHENOLS AND SELECTIVE CYCLOOXYGENASE-2 INHIBITORS ON THE GROWTH OF HUMAN PROSTATE CANCER CELLS BOTH IN VITRO AND IN VIVO.
ADHAMI VM,MALIK A,ZAMAN N,ET AL.
CLIN CANCER RES 2007 Vol.13(5),1611-9 354285 [Abstract]

Part Used : -
Activity : CELL GROWTH INHIBITION EFFECT

Solvent/Active Compound : (-)epigallocatechin-3-gallate (EGCG)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 10-40 micromolar/L

Duration : -
Type of interaction : P.Kinetics & P.Dynamics

Interaction with drug : NS-398
Dose/Conc.(drug) : 10 micromolar/L

Result : Positive

Remark : Type of experiment: human prostate cancer cells LNCaP, PC-3, and CWR22Rn1 Results: Combination of EGCG and NS-398 resulted in enhanced (a) cell growth inhibition; (b) apoptosis induction; (c) expression of Bax, pro-caspase-6, and pro-caspase-9, and poly (ADP) ribose polymerase cleavage; (d) inhibition of peroxisome proliferator activated receptor g; and (e) inhibition of nuclear factor-kB compared with the additive effects of the two agents alone, suggesting a possible synergism.

Note : Data incomplete

หน้า 1 2 3

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