ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ไม่ระบุ

Activity : DRUG INTERACTION

Solvent/Active Compound : (-)-epigallocatechin-3-gallate (EGCG)

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : 150 mg/kg

Duration : 30 min.*

Type of interaction : Pharmacokinetics

Interaction with drug : Nadolol*/Corgard

Dose/Conc.(drug) : 10 mg/kg

Result : Positive

Remark : - Pretreatment with GTE resulted in marked reductions in the maximum concentration (Cmax) and area under the time-plasma concentration curve (AUC) of nadolol by 85% and 74%, respectively, as compared with control. In addition, EGCG alone significantly reduced Cmax and AUC of nadolol. Amounts of nadolol excreted into the urine were decreased by pretreatments with GTE and EGCG, while the terminal half-life on nadolol was not different among groups.

Note : Duration: *Rats received green tea extract (GTE) and (-)-epigallocatechin-3-gallate (EGCG) or saline (control) by oral gavage, 30 min before a single intragastric administratiion of nadolol. - These results suggest that the coadministration with green tea catechins, particularly EGCG, causes a significant alteration in the pharmacokinetics of nadolol.

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