THEACEAE Camellia sinensis  (L.) Kuntze

 Synonym

  • THEACEAE Thea sinensis  L.
  • THEACEAE Camellia sinensis  (L.) Kuntze var. assamica (Mast.) Kitam.
 Thai / English name

  • ชา*

[1-1] of 1 article(s) found

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[1] EPIGALLOCATECHIN GALLATE, ELLAGIC ACID, AND ROSMARINIC ACID PERTURB DNTP POOLS AND INHIBIT DE NOVO DNA SYNTHESIS AND PROLIFERATION OF HUMAN HL-60 PROMYELOCYTIC LEUKEMIA CELLS: SYNERGISM WITH ARABINOFURANOSYLCYTOSINE.
PHILIPP SAIKO, MARIE-THERESE STEINMANN, HEIKE SCHUSTER,ET AL.
PHYTOMEDICINE 2015 Vol.22(),213-22  $54161 [Full]

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT
Solvent/Active Compound : EA
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 10 micromolar/nM
Duration : 24 h.
Type of interaction : Pharmacodynamics
Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 10 micromolar/nM
Result : Positive
Remark : - Cell number (% of control) 81.7 - Combination index 1.079 - Four out of nine EA combinations applied showed synergism.
Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION
Solvent/Active Compound : EA
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 10 micromolar/nM
Duration : 24 h.
Type of interaction : Pharmacodynamics
Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 10 micromolar/nM
Result : Positive
Remark : - Cell number (% of control) 81.7 - Combination index 1.079 - Four out of nine EA combinations applied showed synergism.
Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION
Solvent/Active Compound : EA
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 10 micromolar/nM
Duration : 24 h.
Type of interaction : Pharmacodynamics
Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 20 micromolar/nM
Result : Positive
Remark : - Cell number (% of control) 74.4 - Combination index 0.916 - Four out of nine EA combinations applied showed synergism.
Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT
Solvent/Active Compound : EA
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 10 micromolar/nM
Duration : 24 h.
Type of interaction : Pharmacodynamics
Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 20 micromolar/nM
Result : Positive
Remark : - Cell number (% of control) 74.4 - Combination index 0.916 - Four out of nine EA combinations applied showed synergism.
Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION
Solvent/Active Compound : EA
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 20 micromolar/nM
Duration : 24 h.
Type of interaction : Pharmacodynamics
Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 5 micromolar/nM
Result : Positive
Remark : - Cell number (% of control) 84.0 - Combination index 1.055 - Four out of nine EA combinations applied showed synergism.
Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT
Solvent/Active Compound : EA
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 20 micromolar/nM
Duration : 24 h.
Type of interaction : Pharmacodynamics
Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 5 micromolar/nM
Result : Positive
Remark : - Cell number (% of control) 84.0 - Combination index 1.055 - Four out of nine EA combinations applied showed synergism.
Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION
Solvent/Active Compound : EA
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 20 micromolar/nM
Duration : 24 h.
Type of interaction : Pharmacodynamics
Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 10 micromolar/nM
Result : Positive
Remark : - Cell number (% of control) 78.5 - Combination index 0.939 - Four out of nine EA combinations applied showed synergism.
Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT
Solvent/Active Compound : EA
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 20 micromolar/nM
Duration : 24 h.
Type of interaction : Pharmacodynamics
Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 10 micromolar/nM
Result : Positive
Remark : - Cell number (% of control) 78.5 - Combination index 0.939 - Four out of nine EA combinations applied showed synergism.
Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION
Solvent/Active Compound : EA
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 20 micromolar/nM
Duration : 24 h.
Type of interaction : Pharmacodynamics
Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 20 micromolar/nM
Result : Positive
Remark : - Cell number (% of control) 71.0 - Combination index 0.797 (Synergistic combination effect). - Four out of nine EA combinations applied showed synergism.
Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT
Solvent/Active Compound : EA
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 20 micromolar/nM
Duration : 24 h.
Type of interaction : Pharmacodynamics
Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 20 micromolar/nM
Result : Positive
Remark : - Cell number (% of control) 71.0 - Combination index 0.797 (Synergistic combination effect). - Four out of nine EA combinations applied showed synergism.
Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC


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