Part Used : ใบ
Activity : CYP3A4 INDUCTION
Solvent/Active Compound : -
Type of experiment : human
Type of animal : -
Type of study : Case report
N(Total) : 1
N(Treatment) : 1
Route : Oral administration
Dose/Conc.(herb) : 1 g/ die of catechins
Duration : 10 days
Type of interaction : Pharmacokinetics
Interaction with drug : Irbesartan
Dose/Conc.(drug) : 150 mg/day
Remark : The patient, carrying genetic variant of hepatic metabolism making her particularly susceptible to oxidative stress, developed an abnormal response to a mild toxic insult, afforded by a combination of agents (oral contraceptives + irbesartan + green tea) that normally would not be able to cause damage. Her particular hepatic metabolism might have further increased the drugs' concentration, favoring the haptenization of liver proteins, eventually leading to the development of an autoimmune hepatitis.