Part Used : -
Activity : CYP2C9 INHIBITION
Solvent/Active Compound : -
Type of experiment : human
Type of animal : -
Type of study : Cross over
N(Total) : 14 (M/F=11/3)
N(Treatment) : 14 (M/F=11/3)
Sex : Both sex
Age : 29+/-8 years (range 19-41 years)
Route : Oral administration
Dose/Conc.(herb) : 8 oz.
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Flurbiprofen
Dose/Conc.(drug) : 100 mg
Remark : Subject: Healthy volunteers received 100 mg flurbiprofen on 5 occasions in a crossover fashion, with at least 1 week separating the 5 trials. Flurbiprofen was preceded in radom sequence by the following: (1) cranberry juice placebo (8 oz.), (2) cranberry juice (8 oz), (3) brewed tea (8 oz), (4) grape juice (8 oz), and (5) fluconazole, a CYP2C9 inhibitor serving as a positive control, with 8 oz of water.
Results: none of the 3 beverages (cranberry juice, grape juice and tea) altered CYP2C9-mediated clearance of flurbiprofen in humans.