Part Used : -
Activity : DRUG INTERACTION
Solvent/Active Compound : epigallocatechin-gallate (EGCG), (+)-catechin (C), (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin-gallate (ECG)
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : -
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Tacrolimus
Dose/Conc.(drug) : -
Remark : The combined treatment with 5 micromolar EGCG and 5 micromolar of C, EC, EGC or ECG reduced FK506 (tacrolimus)-induced cytotoxicity in LLC-PK1. Similarty, the combined treatment with 5 micromolar EGC and 5 micromolar of C, EC, EGCG or ECG also reduced the cytotoxicity.