Part Used : ใบ
Activity : DRUG INTERACTION
Solvent/Active Compound : green tea extract
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : 25 microgram/ml
Duration : 5 minutes
Type of interaction : Pharmacokinetics
Interaction with drug : Midazolam*/Versed/Dormicum
Dose/Conc.(drug) : -
Remark : - Details of the standardized Green tea extracts: 99.61% Tea polyphenols, 65.38% EGCG, 82.79% Catechins, 1.17% Caffeine, 3.98% Water, 0.18% Sulfated ash.
- Results: The degree of CYP3A4 inhibition of Ginkgo biloba was 93.8% and IC50 values of that inhibit CYP3A4-mediated metabolism of midazolam = 9.96 microgram/ml, 95% Cl: 5.41-18.3.
Note : The effects of complementary and alternative medicine (CAM) on CYP3A4-mediated metabolism of midazolam and docetaxel were determined in human liver microsomes (HLM), using liquid-chromatography coupled to tandem mass spectrometry (LC-MS/MS).