Part Used : ใบ
Activity : CYP3A4 INHIBITION
Solvent/Active Compound : green tea extract
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : 100 microgram/ml
Duration : 30 minutes
Type of interaction : Pharmacokinetics
Interaction with drug : Docetaxel*/Taxotere
Dose/Conc.(drug) : -
Remark : - Details of the standardized Green tea extract: 99.61% Tea polyphenols, 65.38% EGCG, 82.79% Catechins, 1.17% Caffeine, 3.98% Water, 0.18% Sulfated ash.
- Results: The degree of CYP3A4 inhibition of Ginkgo biloba was 90.9% and IC50 values of that inhibit CYP3A4-mediated metabolism of docetaxel = 42.3 microgram/ml, 95% Cl: 36.2-49.4.
Note : The effects of complementary and alternative medicine (CAM) on CYP3A4-mediated metabolism of midazolam and docetaxel were determined in human liver microsomes (HLM), using liquid-chromatography coupled to tandem mass spectrometry (LC-MS/MS).