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Part Used : เมล็ดActivity : CYP3A4 INHIBITIONSolvent/Active Compound : n-HexaneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 micromolar/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Inhibition (%)=74
Part Used : เมล็ดActivity : CYP3A4 INHIBITIONSolvent/Active Compound : EtOAcType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 micromolar/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Inhibition (%)=88
Part Used : เมล็ดActivity : CYP3A4 INHIBITIONSolvent/Active Compound : n-BuOHType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 micromolar/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Inhibition (%)=56
Part Used : เมล็ดActivity : CYP3A4 INHIBITIONSolvent/Active Compound : waterType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 micromolar/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Inhibition (%)=8
Part Used : เมล็ดActivity : CYP3A4 INHIBITIONSolvent/Active Compound : ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The selective inhibitor ketoconazole showed the most potent inhibitory activity on CYP3A4 with mean IC50 of 0.23 microgram/mL. PC, DM, DL, PI were most potent with mean IC 1.54-6.43 microgram/mL. PC exhibited similar inhibitory activity to ketoconazole (p > 0.05). GM and ZO exhibitied moderate potencies (mean IC50 11.33 and 11.58 microgram/mL, respectively). MF and AL exhibited relatively low potencies (mean IC50 41.91 and 54.36 microgram/mL, respectively) (substrate:nifedipine)Note : Piper chaba (PC), Dioscroea membranacea (DI), Dracaenal oureiri (DG), Atractylodes lancea (AL), Plumbago indica (PI), Zingiber officinale (ZO), Myristica fragrans (MF), Garcinia mangostana (GM).
