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| Thai / English name |
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : macelignan (phytoestrogen)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 20 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paclitaxel*/Taxol/PTXDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: NCI/ADR-RES cells Results: Macelignan increased the cellular accumulation of paclitaxel by approximately 1.7 fold in NCI/ADR-RES cells overexpressing P-gp, while it did not alter the cellular accumulation of paclitaxel in OVCAR-8 cells lacking P-gp.Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : macelignan (phytoestrogen)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 20 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paclitaxel*/Taxol/PTXDose/Conc.(drug) : -Result : NegativeRemark : Type of experiment: OVCAR-8 cells Results: Macelignan increased the cellular accumulation of paclitaxel by approximately 1.7 fold in NCI/ADR-RES cells overexpressing P-gp, while it did not alter the cellular accumulation of paclitaxel in OVCAR-8 cells lacking P-gp.Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : macelignan (phytoestrogen)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : 20 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paclitaxel*/Taxol/PTXDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: oral administration of paclitaxel with and without macelignan. Results: The concurrent use of macelignan significantly enhanced the oral exposure of paclitaxel in rats while it did not affect the intravenous pharmacokinetics of paclitaxel, implying that macelignan might be more effective to improve the intestinal absorption rather than reducing hepatic elimination.Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : macelignan (phytoestrogen)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : 20 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paclitaxel*/Taxol/PTXDose/Conc.(drug) : -Result : NegativeRemark : Type of experiment: intrevanous administration of paclitaxel with and without macelignan. Results: The concurrent use of macelignan significantly enhanced the oral exposure of paclitaxel in rats while it did not affect the intravenous pharmacokinetics of paclitaxel, implying that macelignan might be more effective to improve the intestinal absorption rather than reducing hepatic elimination.Note : Data incomplete
