Part Used : เมล็ด
Activity : DRUG INTERACTION
Solvent/Active Compound : n-3 alpha-linoleinc acid-rich perilla oil (P-oil)
Type of experiment : in vivo
Type of animal : rat
N(Total) : -
N(Treatment) : -
Route : Oral administration
Dose/Conc.(herb) : 10% perilla oil plus 40 ppm indomethacin in their drinking water
Duration : 32 weeks
Type of interaction : Pharmacodynamics
Interaction with drug : Indomethacin*/Indometacin
Dose/Conc.(drug) : indomethacin 40 ppm in the drinking water
Remark : Result: The average final body weights of the animals significant increases were observed in the groups treated with perilla oil + indomethacin and perilla oil compared with the control group.
Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
