Part Used : เมล็ด
Activity : ANTITUMOR ACTIVITY
Solvent/Active Compound : n-3 alpha-linoleinc acid-rich perilla oil (P-oil)
Type of experiment : in vivo
Type of animal : rat
N(Total) : -
N(Treatment) : -
Route : Oral administration
Dose/Conc.(herb) : 10% perilla oil plus 40 ppm indomethacin in their drinking water
Duration : 32 weeks
Type of interaction : Pharmacodynamics
Interaction with drug : Indomethacin*/Indometacin
Dose/Conc.(drug) : indomethacin 40 ppm in the drinking water
Remark : Result: For colon tumors, perilla oil in combination with indomethacin significantly decreased both the incidence and multiplicity of adenomas in comparison with perilla oil alone. However, strict summation or synergism was not observed.
Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
