| Synonym |
| Thai / English name |
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Essential oilType of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 354* (M/F=114/240)N(Treatment) : 5 of 29Sex : Both sexAge : The majorities (40.1%) of the respondents' were between 35-44 yrs.Route : Oral administrationDose/Conc.(herb) : Half cup/glass (6.9%), 1 cup/glass (6.9%), 1-2 spoonful (10.3%) (data analyzed from 29 of 354 patients who used herbal drugs)Duration : Once daily (58.6%), many times daily (6.9%), weekly (10.3%), occasionally (24.1%) (data analyzed from 29 of 354 patients who used herbal drugs)Type of interaction : Non-specifiedInteraction with drug : Lamivudine*/3TCDose/Conc.(drug) : -Result : PositiveRemark :Note : *Subject total: Subjects were HIV patients. **Subject treatment: 29 of 354 patients used herbal drugs. Result: A marginal improvement though not significant (p>/=0.05) in the CD4 counts (489.8+/-195.2; 419.1+/-236.2) and viral load (5117.8+/-26092.0;31136.7+/-197954.6) of HIV patients on herbal drugs compared to those who are not on herbal drugs. There are no significant associations (p>/=0.05) between socio-demographic data and use of herbal medicine. However, there is a significant difference (p
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Essential oilType of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 354* (M/F=114/240)N(Treatment) : 5 of 29Sex : Both sexAge : The majorities (40.1%) of the respondents' were between 35-44 yrs.Route : Oral administrationDose/Conc.(herb) : Half cup/glass (6.9%), 1 cup/glass (6.9%), 1-2 spoonful (10.3%) (data analyzed from 29 of 354 patients who used herbal drugs)Duration : Once daily (58.6%), many times daily (6.9%), weekly (10.3%), occasionally (24.1%) (data analyzed from 29 of 354 patients who used herbal drugs)Type of interaction : Non-specifiedInteraction with drug : NevirapineDose/Conc.(drug) : -Result : PositiveRemark :Note : *Subject total: Subjects were HIV patients. **Subject treatment: 29 of 354 patients used herbal drugs. Result: A marginal improvement though not significant (p>/=0.05) in the CD4 counts (489.8+/-195.2; 419.1+/-236.2) and viral load (5117.8+/-26092.0;31136.7+/-197954.6) of HIV patients on herbal drugs compared to those who are not on herbal drugs. There are no significant associations (p>/=0.05) between socio-demographic data and use of herbal medicine. However, there is a significant difference (p
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 250N(Treatment) : 187Sex : Both sexAge : 69+/-10 yrs.Route : Oral administrationDose/Conc.(herb) : Consumption of herbs at least 4 times per weekDuration : -Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : Consumption of herbs at least 4 times per week was associated with suboptimal anticoagulation control with warfarin. Patients treated with warfarin should not only be aware of the intake of herbal drugs but also of foods with herbal ingredients such as garlic, ginger, and papaya.Note : Patients with atrial fibrillation (AF) who were prescribed warfarin therapy for at least 6 months before the study were recruited from the medical and cardiac clinics.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : garlic - derived diallyl sulfoneType of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : FemaleAge : 75 yrsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : This concern is borne out of a case report that a 75 - year - old women on chronic warfarin therapy had an increase in her INR after initiating therapy with ginger, complicated by epistaxis, which returned to normal after discontiuation of ginger and after treatment with vitamin K.Note : Data incomplete, data from review article
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : garlic - derived diallyl sulfoneType of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : FemaleAge : 76 yrsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : A similar case report describes a 76 - year - old woman who experienced erratic anticoagulation after taking ginger.Note : Data incomplete, data from review article
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 12N(Treatment) : 12Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 400 mg, 3 times per dayDuration : 1 week before warfarin and was continued for a further 1 week after itType of interaction : P.Kinetics & P.DynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : In an open - label, three - way crossover, randomized study in 12 healthy volunteers, ginger was given orally at a dose of 400 mg (three times per day for 1 week) before warfarin and was continued for a further 1 week after it. Ginger was found to exert no significant effect on either the pharmacokinetics or the pharmacodynamics of warfarin in healthy subjects.Note : Data incomplete, data from review article
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Double-blind trialN(Total) : 12N(Treatment) : 12Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 400 mg, 3 times per dayDuration : 1 week before warfarin and was continued for a further 1 week after itType of interaction : P.Kinetics & P.DynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : In an open - label, three - way crossover, randomized study in 12 healthy volunteers, ginger was given orally at a dose of 400 mg (three times per day for 1 week) before warfarin and was continued for a further 1 week after it. Ginger was found to exert no significant effect on either the pharmacokinetics or the pharmacodynamics of warfarin in healthy subjects.Note : Data incomplete, data from review article
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 1818N(Treatment) : 7Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : In a recent cross - sectional point - of - care survey of 1818 patients, seven cases involving coadministered warfarin and ginger identified a potential clinically significant interaction between the anticoagulant/platelets and ginger.Note : Data incomplete, data from review article
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1 gDuration : -Type of interaction : PharmacodynamicsInteraction with drug : NifedipineDose/Conc.(drug) : 10 mg/dayResult : PositiveRemark : It was reported that either aspirin or ginger could potentiated the antiplatelet aggregation effect of nifedipine in both patient sets. These results suggested a synergistic effect of ginger and nifedipine on antiplatelet aggregation. It has been recommended that 1 g ginger combined with 10 mg nifedipine/day could potentially combat cardiovascular and cerebrovascular complicaiton due to platelet aggregation.Note : Data incomplete, data from review article
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The selective inhibitor of CYP1A2 alpha-naphthoflavone exhibited the most potent inhibitory activity on enzyme activity with mean IC50 of 0.01 microgram/mL. PC and AL exhibited most potent activity with IC50 values in a similar range of that of the alpha-naphthoflavone (p > 0.05). DM, DL, GM and ZO exhibited moderate potencies (IC50 1.04-9.87 microgram/mL), whereas PI and MF exhibited relatively low potencies (IC50 12.95 and 22.05 microgram/mL, respectively) (Substrate=phenacetin)Note : Piper chaba (PC), Dioscroea membranacea (DI), Dracaenal oureiri (DG), Atractylodes lancea (AL), Plumbago indica (PI), Zingiber officinale (ZO), Myristica fragrans (MF), Garcinia mangostana (GM).
