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Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 10N(Treatment) : 10Sex : Both sexAge : 35-60 yearsRoute : Oral administrationDose/Conc.(herb) : 1 gDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : NifedipineDose/Conc.(drug) : 10 mgResult : PositiveRemark : Subjects: hypertensive patients Results: After the treatment of the combination of nifedipine and ginger, the percentage of inhibition values with the three agonist were 64.2%, 63.8%, 61.1% respectively in hypertensive patients.
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : Ginger juice/ 6-gingerolType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : ginger juice 5 mL/kg (contain 5.2 mg/kg) combination with CyclosporineDuration : concomitantlyType of interaction : PharmacokineticsInteraction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyADose/Conc.(drug) : -Result : PositiveRemark : The results indicated that concomitant intake of ginger juice and its administration 2 hours before cyclosporine significantly decrease Cmax of cyclosporine by 70.9% and 51.4% and reduced AUC0-540 by 63.1% and 40.3%, respectively
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : Ginger juiceType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : ginger juice 5 mL/kg combination with CyclosporineDuration : 2 h before administration of cyclosporineType of interaction : PharmacokineticsInteraction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyADose/Conc.(drug) : -Result : PositiveRemark : The results indicated that concomitant intake of ginger juice and its administration 2 hours before cyclosporine significantly decrease Cmax of cyclosporine by 70.9% and 51.4% and reduced AUC0-540 by 63.1% and 40.3%, respectively
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 microgram/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : IC50=5.1 microgram/ml
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 microgram/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : IC50=10.0 microgram/ml
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : TrikatuType of experiment : in vivoType of animal : otherType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 2 g/kg dailyDuration : 15 daysType of interaction : PharmacokineticsInteraction with drug : PefloxacinDose/Conc.(drug) : -Result : PositiveRemark : The mean plasma concentrations of pefloxacin were consistently lower in trikatu treated goats up to 2 h compared with control animal. The bioavailability of the drug was also significantly higher in trikatu treated goats (44.18+/-2.90% against 38.33 +/-1.80% incontrol animals). Prior treatment of the goats with trikatu significantly reduced the elimination half-life (t1/2Beta) and the zero time intercept of the elimination phase. The indicators of drug distribution in the body i.e. apparent volume of distribution and volume of distribution based on the zero time plasma drug concentration intercept of the elimination phase were significantly higher in the trikatu treated goats.Note : Trikatu prepared from equal parts of Piper longum, Piper nigrum and Zingiber officinale. Type of animal = goat
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mL/kg for ginger juiceDuration : Single administrationType of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : The AUC values of tacrolimus in the rat pre-treated with grapefruit juice, ginger juice, and turmeric juice were significantly larger than those pre-treated with water. These AUC values were almost equal to the values for those pre-treated with 100% pomelo juice.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : waterType of experiment : in vivoType of animal : rabbitType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 4 ml/kgDuration : 30 mins prior to drug administrationType of interaction : PharmacokineticsInteraction with drug : PefloxacinDose/Conc.(drug) : -Result : PositiveRemark : Ginger increased the maximal concentration of pefloxacin from 2.55+/-0.794 when administered alone to 2.96+/-0.746 when administered witn ginger showing a 16.00% increase in the absorbed drug. The prior administration of ginger to the rabbits lead to significant increases in AUC and AUMC of pefloxacin for 72.34% and 91.91% change, respectively. The half-life of pefloxacin produced a marginally significant 56.08% increase in the presence of ginger. Furthermore, the clearance of pefloxcin and its volume of distribution were significantly decreased when administered in the presence of ginger.Note : The study was conduced into 2 phases. In phase I, rabbits were given only Pefloxacin (100 mg/kg) and phase II, the rabbits were given 4 ml/kg of ginger extract 30 mins prior to drug administration. The ginger extract prepared from the cold maceration of 20 g powder with 250 ml water.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : waterType of experiment : in vivoType of animal : rabbitType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1 ml/kg dailyDuration : 3 days with 2-week washout periodType of interaction : PharmacokineticsInteraction with drug : MetronidazoleDose/Conc.(drug) : -Result : PositiveRemark : The peak (Cmax) in the plasma concentration-time curve of metronidazole plus ginger occurred about 4h while metronidazole alone was in 2h post administration, indicated that ginger may have caused delay in the rate of absorption of oral metronidazole. The metronidazole clearance and the elimination rate were reduced in metronidazole plus ginger group (phase II)Note : The study design into 2 phases. In phase I, rabbits were given only metronidazole and phase II, the rabbits were given 1 ml/kg of ginger extract per oral daily for 3 days and immediately given 3 mg/kg metronidazole per oral on the third day.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : 60% ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Herbal solution (100 microlitre, seven different concentrations for each herb ranging from 4 to 28000 microgram/ml in 4% ethanol)Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The IC50 constants of ginger extract for CYP1A2, CYP2D6, and CYP3A4 inhibition were 320+/-41, 445+/-35, and 565+/-16 microgram/ml, respectively.
