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Part Used : ผลActivity : CYP3A4 INHIBITIONSolvent/Active Compound : Trikatu laboratory formulation / DMSOType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 800-6.5 micrograms/mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: IC50 value of extracts on metabolism mediated by CYP3A4 and CYP2D6 were 223.254+/-0.92 and 245.23+/-1.92 micrograms/mL, respectively.Note : Type of experiment: rat liver microsomes. The amount of 6-gingerol present in extract of Zingiber officinal, Trikatumarketed formulation and Trikatu laboratory formulation was estimated to be about 6.21+/-1.03%, 5.3+/-1.21% and 4.95+/-2.34% (w/w), respectively. Piperine was found to be 7.31+/-2.36% (Piper longum), 8.41+/-2.54% (Piper nigrum), 7.89+/-2.12% (Trikatu marketed formulation) and 6.70+/-2.13% (w/w) (Trikatu laboratory formulation).
Part Used : เหง้าActivity : CYP3A4 INHIBITIONSolvent/Active Compound : ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The selective inhibitor ketoconazole showed the most potent inhibitory activity on CYP3A4 with mean IC50 of 0.23 microgram/mL. PC, DM, DL, PI were most potent with mean IC 1.54-6.43 microgram/mL. PC exhibited similar inhibitory activity to ketoconazole (p > 0.05). GM and ZO exhibitied moderate potencies (mean IC50 11.33 and 11.58 microgram/mL, respectively). MF and AL exhibited relatively low potencies (mean IC50 41.91 and 54.36 microgram/mL, respectively) (substrate:nifedipine)Note : Piper chaba (PC), Dioscroea membranacea (DI), Dracaenal oureiri (DG), Atractylodes lancea (AL), Plumbago indica (PI), Zingiber officinale (ZO), Myristica fragrans (MF), Garcinia mangostana (GM).
Part Used : เหง้าActivity : CYP3A4 INHIBITIONSolvent/Active Compound : 10-gingerolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The results showed 10-gingerol (IC50 5.75 microM) is isolated from EtOAc extract of ginger show remarkable inhibitory activity compared to 6-gingerol (IC50 14.56 microM) and zingerone (IC50 379.63 microM).Note : Data incomplete
Part Used : ไม่ระบุActivity : CYP3A4 INHIBITIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Ginger fraction, use thereof on its own or combined with drugs for inhibiting human cytochrome P450 (CYP) enzymes (particularly cytochrome P 450 3A4, CYP3A4) for positive influencing the oral bioavailablity and pharmacokinetics of active substance.Note : Data incomplete from abstract
Part Used : ไม่ระบุActivity : CYP3A4 INHIBITIONSolvent/Active Compound : Ginger fractionType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : -Remark :Note : Data incomplete
Part Used : เหง้าActivity : CYP3A4 INHIBITIONSolvent/Active Compound : ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The ethanolic extract of Zingiber officinale inhibited CYP3A4 activity with IC50 value 30.3+/-15.1 microgram/ml.Note : Testosterone 6beta-hydroxylase and dextromethorphan O-demethylase were used as maker of CYP3A4 and CYP2D6 activity, respectively.
Part Used : เหง้าActivity : CYP3A4 INHIBITIONSolvent/Active Compound : ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The aqueous extract of Zingiber officinale inhibited CYP3A4 activity with IC50 value 270+/-79.4 microgram/ml.Note : Testosterone 6beta-hydroxylase and dextromethorphan O-demethylase were used as maker of CYP3A4 and CYP2D6 activity, respectively.
