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Part Used : เหง้าActivity : CYP2D6 INHIBITIONSolvent/Active Compound : Trikatu laboratory formulation / DMSOType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 800-6.5 micrograms/mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: IC50 value of extracts on metabolism mediated by CYP3A4 and CYP2D6 were 223.254+/-0.92 and 245.23+/-1.92 micrograms/mL, respectively.Note : Type of experiment: rat liver microsomes. The amount of 6-gingerol present in extract of Zingiber officinal, Trikatumarketed formulation and Trikatu laboratory formulation was estimated to be about 6.21+/-1.03%, 5.3+/-1.21% and 4.95+/-2.34% (w/w), respectively. Piperine was found to be 7.31+/-2.36% (Piper longum), 8.41+/-2.54% (Piper nigrum), 7.89+/-2.12% (Trikatu marketed formulation) and 6.70+/-2.13% (w/w) (Trikatu laboratory formulation).
Part Used : ผลActivity : CYP2D6 INHIBITIONSolvent/Active Compound : Trikatu laboratory formulation / DMSOType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 800-6.5 micrograms/mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: IC50 value of extracts on metabolism mediated by CYP3A4 and CYP2D6 were 223.254+/-0.92 and 245.23+/-1.92 micrograms/mL, respectively.Note : Type of experiment: rat liver microsomes. The amount of 6-gingerol present in extract of Zingiber officinal, Trikatumarketed formulation and Trikatu laboratory formulation was estimated to be about 6.21+/-1.03%, 5.3+/-1.21% and 4.95+/-2.34% (w/w), respectively. Piperine was found to be 7.31+/-2.36% (Piper longum), 8.41+/-2.54% (Piper nigrum), 7.89+/-2.12% (Trikatu marketed formulation) and 6.70+/-2.13% (w/w) (Trikatu laboratory formulation).
Part Used : เหง้าActivity : CYP2D6 INHIBITIONSolvent/Active Compound : ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The selective inhibitor quinidine showed the most potent inhibitory activity on CYP2D6 activity with mean IC50 of 0.97 microgram/mL. DM, DL and PI showed the highest inhibitory activities (mean IC50 2.93-9.57 microgram/mL). The potency of inhibitory activity of DM was comparable to that of quinidine (p > 0.05). PC, GM and ZO exhibited moderate potencies (mean IC50 23.40-31.32 microgram/mL), and MF and AL exhibited relatively low potencies (mean IC50 195.83 and 313.51 microgram/mL, respectively). (substrate: extromethorphan)Note : Piper chaba (PC), Dioscroea membranacea (DI), Dracaenal oureiri (DG), Atractylodes lancea (AL), Plumbago indica (PI), Zingiber officinale (ZO), Myristica fragrans (MF), Garcinia mangostana (GM).
