ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : เหง้า

Activity : EFFECTS ON PHARMACOKINETIC

Solvent/Active Compound : water

Type of experiment : in vivo

Type of animal : rabbit

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : 1 ml/kg daily

Duration : 3 days with 2-week washout period

Type of interaction : Pharmacokinetics

Interaction with drug : Metronidazole

Dose/Conc.(drug) : -

Result : Positive

Remark : The peak (Cmax) in the plasma concentration-time curve of metronidazole plus ginger occurred about 4h while metronidazole alone was in 2h post administration, indicated that ginger may have caused delay in the rate of absorption of oral metronidazole. The metronidazole clearance and the elimination rate were reduced in metronidazole plus ginger group (phase II)

Note : The study design into 2 phases. In phase I, rabbits were given only metronidazole and phase II, the rabbits were given 1 ml/kg of ginger extract per oral daily for 3 days and immediately given 3 mg/kg metronidazole per oral on the third day.

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