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Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : TrikatuType of experiment : in vivoType of animal : otherType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 2 g/kg dailyDuration : 15 daysType of interaction : PharmacokineticsInteraction with drug : PefloxacinDose/Conc.(drug) : -Result : PositiveRemark : The mean plasma concentrations of pefloxacin were consistently lower in trikatu treated goats up to 2 h compared with control animal. The bioavailability of the drug was also significantly higher in trikatu treated goats (44.18+/-2.90% against 38.33 +/-1.80% incontrol animals). Prior treatment of the goats with trikatu significantly reduced the elimination half-life (t1/2Beta) and the zero time intercept of the elimination phase. The indicators of drug distribution in the body i.e. apparent volume of distribution and volume of distribution based on the zero time plasma drug concentration intercept of the elimination phase were significantly higher in the trikatu treated goats.Note : Trikatu prepared from equal parts of Piper longum, Piper nigrum and Zingiber officinale. Type of animal = goat
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : waterType of experiment : in vivoType of animal : rabbitType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 4 ml/kgDuration : 30 mins prior to drug administrationType of interaction : PharmacokineticsInteraction with drug : PefloxacinDose/Conc.(drug) : -Result : PositiveRemark : Ginger increased the maximal concentration of pefloxacin from 2.55+/-0.794 when administered alone to 2.96+/-0.746 when administered witn ginger showing a 16.00% increase in the absorbed drug. The prior administration of ginger to the rabbits lead to significant increases in AUC and AUMC of pefloxacin for 72.34% and 91.91% change, respectively. The half-life of pefloxacin produced a marginally significant 56.08% increase in the presence of ginger. Furthermore, the clearance of pefloxcin and its volume of distribution were significantly decreased when administered in the presence of ginger.Note : The study was conduced into 2 phases. In phase I, rabbits were given only Pefloxacin (100 mg/kg) and phase II, the rabbits were given 4 ml/kg of ginger extract 30 mins prior to drug administration. The ginger extract prepared from the cold maceration of 20 g powder with 250 ml water.
