| Synonym |
| Thai / English name |
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12N(Treatment) : 12Sex : MaleAge : 20-36 yrsRoute : Oral administrationDose/Conc.(herb) : 3 tablets x 3 times dailyDuration : 1 week with at least 14-day washoutType of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : There were no significant changes observed in the pharmacokinetic parameters of S- or R-warfarin in healthy male subjects following treatment with ginkgo or ginger. The urinary excretion rate of S-7-hydroxywarfarin after administration of warfarin alone was no significant difference following treatment with either ginkgo or ginger.Note : Each ginger tablet containing 0.4 g of ginger rhizome powder Each Gingko tablet equivalent to 2 g of Ginkgo biloba leaf (9.6 mg of ginkgo flavonglycosides, 2.4 mg of ginkgolides and bilobalide)
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 12N(Treatment) : 12Sex : MaleAge : 20-36 yrsRoute : Oral administrationDose/Conc.(herb) : 3 tablets x 3 times dailyDuration : 1 week with at least 14-day washoutType of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : There were no significant changes observed in the pharmacokinetic parameters of S- or R-warfarin in healthy male subjects following tretment with ginkgo or ginger. The urinary excretion rate of S-7-hydroxywarfarin after administration of warfarin alone was no significant difference following treatment with either ginkgo or ginger.Note : Each ginger tablet containing 0.4 g of ginger rhizome powder Each Gingko tablet equivalent to 2 g of Ginkgo biloba leaf (9.6 mg of ginkgo flavonglycosides, 2.4 mg of ginkgolides and bilobalide)
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 24N(Treatment) : 24Sex : MaleAge : 26 +/- 5 yearsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : WarfarinDose/Conc.(drug) : 25 mgResult : NegativeRemark : Coadministration with either ginkgo or ginger with warfarin did not affect the pharmacokinetics or pharmacodynamics of S-warfarin.Note : Type of clinical study: randomized, open-label, controlled, 3-treatment, and 3-sequence crossover studies with at least a 14-day washout period between study periods of dosing. Subjects: healthy male subjects received a single 25 mg dose warfarin with or without pretreatment with Commission E19 recommended daily doses of St John's wort, Asian ginseng (Panax ginseng), ginkgo (Ginkgo biloba), or ginger from commercially available products of known quality.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 24N(Treatment) : 24Sex : MaleAge : 26 +/- 5 yearsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : WarfarinDose/Conc.(drug) : 25 mgResult : NegativeRemark : Coadministration with either ginkgo or ginger with warfarin did not affect the pharmacokinetics or pharmacodynamics of S-warfarin.Note : Type of clinical study: randomized, open-label, controlled, 3-treatment, and 3-sequence crossover studies with at least a 14-day washout period between study periods of dosing. Subjects: healthy male subjects received a single 25 mg dose warfarin with or without pretreatment with Commission E19 recommended daily doses of St John's wort, Asian ginseng (Panax ginseng), ginkgo (Ginkgo biloba), or ginger from commercially available products of known quality.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 250N(Treatment) : 187Sex : Both sexAge : 69+/-10 yrs.Route : Oral administrationDose/Conc.(herb) : Consumption of herbs at least 4 times per weekDuration : -Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : Consumption of herbs at least 4 times per week was associated with suboptimal anticoagulation control with warfarin. Patients treated with warfarin should not only be aware of the intake of herbal drugs but also of foods with herbal ingredients such as garlic, ginger, and papaya.Note : Patients with atrial fibrillation (AF) who were prescribed warfarin therapy for at least 6 months before the study were recruited from the medical and cardiac clinics.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : garlic - derived diallyl sulfoneType of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : FemaleAge : 75 yrsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : This concern is borne out of a case report that a 75 - year - old women on chronic warfarin therapy had an increase in her INR after initiating therapy with ginger, complicated by epistaxis, which returned to normal after discontiuation of ginger and after treatment with vitamin K.Note : Data incomplete, data from review article
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : garlic - derived diallyl sulfoneType of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : FemaleAge : 76 yrsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : A similar case report describes a 76 - year - old woman who experienced erratic anticoagulation after taking ginger.Note : Data incomplete, data from review article
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 12N(Treatment) : 12Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 400 mg, 3 times per dayDuration : 1 week before warfarin and was continued for a further 1 week after itType of interaction : P.Kinetics & P.DynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : In an open - label, three - way crossover, randomized study in 12 healthy volunteers, ginger was given orally at a dose of 400 mg (three times per day for 1 week) before warfarin and was continued for a further 1 week after it. Ginger was found to exert no significant effect on either the pharmacokinetics or the pharmacodynamics of warfarin in healthy subjects.Note : Data incomplete, data from review article
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Double-blind trialN(Total) : 12N(Treatment) : 12Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 400 mg, 3 times per dayDuration : 1 week before warfarin and was continued for a further 1 week after itType of interaction : P.Kinetics & P.DynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : In an open - label, three - way crossover, randomized study in 12 healthy volunteers, ginger was given orally at a dose of 400 mg (three times per day for 1 week) before warfarin and was continued for a further 1 week after it. Ginger was found to exert no significant effect on either the pharmacokinetics or the pharmacodynamics of warfarin in healthy subjects.Note : Data incomplete, data from review article
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 1818N(Treatment) : 7Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : In a recent cross - sectional point - of - care survey of 1818 patients, seven cases involving coadministered warfarin and ginger identified a potential clinically significant interaction between the anticoagulant/platelets and ginger.Note : Data incomplete, data from review article
