ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ไม่ระบุ

Activity : PHARMACOKINETIC STUDY OF

Solvent/Active Compound : -

Type of experiment : human

Type of animal : -

Type of study : Open trial

N(Total) : 24

N(Treatment) : 24

Sex : Male

Age : 26 +/- 5 years

Route : Oral administration

Dose/Conc.(herb) : -

Duration : -

Type of interaction : P.Kinetics & P.Dynamics

Interaction with drug : Warfarin

Dose/Conc.(drug) : 25 mg

Result : Negative

Remark : Coadministration with either ginkgo or ginger with warfarin did not affect the pharmacokinetics or pharmacodynamics of S-warfarin.

Note : Type of clinical study: randomized, open-label, controlled, 3-treatment, and 3-sequence crossover studies with at least a 14-day washout period between study periods of dosing. Subjects: healthy male subjects received a single 25 mg dose warfarin with or without pretreatment with Commission E19 recommended daily doses of St John's wort, Asian ginseng (Panax ginseng), ginkgo (Ginkgo biloba), or ginger from commercially available products of known quality.

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