| Synonym |
| Thai / English name |
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 20N(Treatment) : 20Sex : Both sexAge : 25-60 yrRoute : Oral administrationDose/Conc.(herb) : 1 g of ginger with 10 mg nifedipine, twice dailyDuration : 1 weekType of interaction : PharmacodynamicsInteraction with drug : NifedipineDose/Conc.(drug) : -Result : PositiveRemark : Phase I: the normal volunteers were administered both ginger and nifedipine in combination, it was observed that the higher percentage inhibition of platelet aggregation induced by collagen, ADP and epinephrine were 79.8%, 75.2% and 69.3%, resp. The results indicated that ginger could potentiate the anti-platelet aggregation of nifedipine.Note : Thie study departed into 2 phases. Phase I: normal volunteer, Phase II: hypertensive patient (10) - All results were similar but higher in phase II of the study.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 20N(Treatment) : 20Sex : Both sexAge : 35-60 yrRoute : Oral administrationDose/Conc.(herb) : 1 g of ginger with 10 mg nifedipine, twice dailyDuration : 1 weekType of interaction : PharmacodynamicsInteraction with drug : NifedipineDose/Conc.(drug) : -Result : PositiveRemark : Phase I: study in hypertensive patients showed that the percentage of inhibition of values with the three agonist was higher (64.2%, 63.8% and 61.1%, resp.) after the treatment with the combination of nifedipone and ginger. The results indicated that ginger could potentiate the anti-platelet aggregation of nifedipine.Note : Thie study departed into 2 phases. Phase I: normal volunteer, Phase II: hypertensive patient (10) - All results were similar but higher in phase II of the study.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 10N(Treatment) : 10Sex : Both sexAge : 25-60 yearsRoute : Oral administrationDose/Conc.(herb) : 1 gDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : NifedipineDose/Conc.(drug) : 10 mgResult : PositiveRemark : Subjects: normal volunteers Results: When the volunteers were administered both ginger and nifedipine in combination, it was observed that the percentage inhibition of platelet aggregation induced by collagen, ADP and epinephrine were 79.8%, 75.2%, 69.3% respectively. These results suggested that ginger and nifedipine possessed synergistic effect on anti-platelet aggregation in normal volunteer.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 10N(Treatment) : 10Sex : Both sexAge : 35-60 yearsRoute : Oral administrationDose/Conc.(herb) : 1 gDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : NifedipineDose/Conc.(drug) : 10 mgResult : PositiveRemark : Subjects: hypertensive patients Results: After the treatment of the combination of nifedipine and ginger, the percentage of inhibition values with the three agonist were 64.2%, 63.8%, 61.1% respectively in hypertensive patients.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1 gDuration : -Type of interaction : PharmacodynamicsInteraction with drug : NifedipineDose/Conc.(drug) : 10 mg/dayResult : PositiveRemark : It was reported that either aspirin or ginger could potentiated the antiplatelet aggregation effect of nifedipine in both patient sets. These results suggested a synergistic effect of ginger and nifedipine on antiplatelet aggregation. It has been recommended that 1 g ginger combined with 10 mg nifedipine/day could potentially combat cardiovascular and cerebrovascular complicaiton due to platelet aggregation.Note : Data incomplete, data from review article
