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ZINGIBERACEAE Zingiber officinale Roscoe

Synonym

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Thai / English name

ขิง*

[1-1] of 1 article(s) found

หน้า 1

[1] GINGER SIGNIFICANTLY DECREASED THE ORAL BIOAVAILABILITY OF CYCLOSPORINE IN RATS.
CHIANG H-M,CHAO P-DL,HSIU S-L,ET AL.
AM J CHIN MED 2006 Vol.34(5),845-55 $30856 [Full]

Part Used : ราก
Activity : DRUG INTERACTION

Solvent/Active Compound : Ginger juice/ 6-gingerol

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : ginger juice 5 mL/kg (contain 5.2 mg/kg) combination with Cyclosporine

Duration : concomitantly
Type of interaction : Pharmacokinetics

Interaction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyA
Dose/Conc.(drug) : -

Result : Positive

Remark : The results indicated that concomitant intake of ginger juice and its administration 2 hours before cyclosporine significantly decrease Cmax of cyclosporine by 70.9% and 51.4% and reduced AUC0-540 by 63.1% and 40.3%, respectively

Part Used : ราก
Activity : DRUG INTERACTION

Solvent/Active Compound : Ginger juice

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : ginger juice 5 mL/kg combination with Cyclosporine

Duration : 2 h before administration of cyclosporine
Type of interaction : Pharmacokinetics

Interaction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyA
Dose/Conc.(drug) : -

Result : Positive

Remark : The results indicated that concomitant intake of ginger juice and its administration 2 hours before cyclosporine significantly decrease Cmax of cyclosporine by 70.9% and 51.4% and reduced AUC0-540 by 63.1% and 40.3%, respectively

หน้า 1

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