Part Used : รำ
Activity : EFFECTS ON PHARMACOKINETIC
Solvent/Active Compound : -
Type of experiment : human
Type of animal : -
Type of study : Cross over
N(Total) : 7
N(Treatment) : 7
Route : Oral administration
Dose/Conc.(herb) : 35 g
Duration : 168 h after the administration of phenprocoumon
Type of interaction : Pharmacokinetics
Interaction with drug : Phenprocoumon*/Phenprocoumarol
Dose/Conc.(drug) : -
Remark : Following the ingestion of wheat bran, a decreased absorption rate for phenprocoumon but no decrease in overall bioavailability was observed. In addition, a decrease in total body clearance of phenprocoumon and an increase in the free plasma fraction of phenprocoumon, resulting in decreased free drug clearance, was seen after wheat bran administration.