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Part Used : เมล็ดActivity : CARCINOGENIC ACTIVITYSolvent/Active Compound : n-6 linoleic acid-rich corn oil (C-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% corn oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : PositiveRemark : Result: For renal cell tumors, corn oil with indomethacin significantly increased the incidence of nephroblastomas.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : เมล็ดActivity : HEPATOTOXIC ACTIVITYSolvent/Active Compound : n-6 linoleic acid-rich corn oil (C-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% corn oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : PositiveRemark : Result: For liver tumors, No nodular lesions, such as HCC and adenomas, were observed in the liver during this study. Treatment with and corn oil alone significantly decreased the numbers and/or areas of GST-P positive foci, putative preneoplastic lesions of the liver, compared with the control group. However, additional treatment with indomethacin tended to abolish the decrease in GST-P positive foci.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : เมล็ดActivity : TUMOR PROMOTING EFFECTSolvent/Active Compound : n-6 linoleic acid-rich corn oil (C-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% corn oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : PositiveRemark : Result: For liver tumors, No nodular lesions, such as HCC and adenomas, were observed in the liver during this study. Treatment with and corn oil alone significantly decreased the numbers and/or areas of GST-P positive foci, putative preneoplastic lesions of the liver, compared with the control group. However, additional treatment with indomethacin tended to abolish the decrease in GST-P positive foci.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : เมล็ดActivity : CARCINOGENIC ACTIVITYSolvent/Active Compound : n-6 linoleic acid-rich corn oil (C-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% corn oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : PositiveRemark : Result: For liver tumors, No nodular lesions, such as HCC and adenomas, were observed in the liver during this study. Treatment with and corn oil alone significantly decreased the numbers and/or areas of GST-P positive foci, putative preneoplastic lesions of the liver, compared with the control group. However, additional treatment with indomethacin tended to abolish the decrease in GST-P positive foci.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : น้ำมันจากเมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : corn oilType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : -Result : PositiveRemark :Note : Result: When indomethacin given with sunflower, corn and olive oils reduced paw edema induced by carrageenan by 79.5%, 74.0% and 60.5%, whereas individual indomethacin and diclofenac reduced paw edema by 56.2% and 50.7%, resp. Besides, the administration of indomethacin together with the vegetable oils and alpha-tocopherol did not cause a statistically significant gastric damage in rats (P > 0.05). However, indomethacin caused statistically significant gastric lesions as compared with untreated rats (P < 0.05). These results suggest that indomethacin as well as other NSAIDs do not have any adverse effect on the gastrointestinal tract when they are used together with vetgetable oils and vitamin E or as the preparations of the oils.
Part Used : น้ำมันจากเมล็ดActivity : GASTROINTESTINAL EFFECTS (UNSPECIFIED)Solvent/Active Compound : corn oilType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : -Result : PositiveRemark :Note : Result: When indomethacin given with sunflower, corn and olive oils reduced paw edema induced by carrageenan by 79.5%, 74.0% and 60.5%, whereas individual indomethacin and diclofenac reduced paw edema by 56.2% and 50.7%, resp. Besides, the administration of indomethacin together with the vegetable oils and alpha-tocopherol did not cause a statistically significant gastric damage in rats (P > 0.05). However, indomethacin caused statistically significant gastric lesions as compared with untreated rats (P < 0.05). These results suggest that indomethacin as well as other NSAIDs do not have any adverse effect on the gastrointestinal tract when they are used together with vetgetable oils and vitamin E or as the preparations of the oils.
Part Used : น้ำมันจากเมล็ดActivity : ANTIINFLAMMATORY ACTIVITY, ANTIARTHRITIS, ANTIIRRITANTSolvent/Active Compound : corn oilType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : -Result : PositiveRemark :Note : Result: When indomethacin given with sunflower, corn and olive oils reduced paw edema induced by carrageenan by 79.5%, 74.0% and 60.5%, whereas individual indomethacin and diclofenac reduced paw edema by 56.2% and 50.7%, resp. Besides, the administration of indomethacin together with the vegetable oils and alpha-tocopherol did not cause a statistically significant gastric damage in rats (P > 0.05). However, indomethacin caused statistically significant gastric lesions as compared with untreated rats (P < 0.05). These results suggest that indomethacin as well as other NSAIDs do not have any adverse effect on the gastrointestinal tract when they are used together with vetgetable oils and vitamin E or as the preparations of the oils.