ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : เมล็ด

Activity : DRUG INTERACTION

Solvent/Active Compound : n-6 linoleinc acid-rich corn oil (C-oil)

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : 10% corn oil plus 40 ppm indomethacin in their drinking water

Duration : 32 weeks

Type of interaction : Pharmacodynamics

Interaction with drug : Indomethacin*/Indometacin

Dose/Conc.(drug) : indomethacin 40 ppm in the drinking water

Result : Equivocal

Remark : Result: The serum PGE2 levels tended to decrease on treatment wih indomethacin (IM) but were increased by corn oil compared with the control level. These latter increases tended to be diminished to the control level with the addition of IM (Corn oil +IM). However, no significant differences were observed between the values.

Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.

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