ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : เมล็ด

Activity : GASTROINTESTINAL EFFECTS (UNSPECIFIED)

Solvent/Active Compound : n-6 linoleic acid-rich corn oil (C-oil)

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : 10% corn oil plus 40 ppm indomethacin in their drinking water

Duration : 32 weeks

Type of interaction : Pharmacodynamics

Interaction with drug : Indomethacin*/Indometacin

Dose/Conc.(drug) : indomethacin 40 ppm in the drinking water

Result : Positive

Remark : Result: For colon tumor, the multiplicity of adenomas was significantly decreased in the indomethacin + corn oil group compared with the corn oil alone group.

Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.

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