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Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : curcuminoidsType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5 mg/kg of body weightDuration : -Type of interaction : PharmacokineticsInteraction with drug : Sulfamethazine*/Sulfadimidine/Sulfadimethyldiazine/SulfamezathineDose/Conc.(drug) : -Result : PositiveRemark : Results: Curcuminoids at 5 mg/kg were able to enhance significantly the absorption rate and peak concentration of sulfamethazine in blood (p<0.05), while those at 10 mg/kg were not. A decrease in clearance and an increase in AUC of the sulfonamide also occurred at the low dose of curcuminoids (p<0.05). At 10 mg/kg, curcuminoids also inhibited the clearance of sulfamazathine which resulted in a significant increase of AUC (p<0.05), but not the elimination half-life of the drug.Note : The animals obtained curcuminoids 5 and 10 mg/kg of body weight orally, one hour prior to an injection of sulfamethazine (50 mg/kg of body weight) i.p. Blood sample (0.2-0.3 mL) were subsequently withdrawn from the tail vein at various time intervals and collected into heparinized tubes.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : curcuminoidsType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mg/kg of body weightDuration : -Type of interaction : PharmacokineticsInteraction with drug : Sulfamethazine*/Sulfadimidine/Sulfadimethyldiazine/SulfamezathineDose/Conc.(drug) : -Result : PositiveRemark : Results: Curcuminoids at 5 mg/kg were able to enhance significantly the absorption rate and peak concentration of sulfamethazine in blood (p<0.05), while those at 10 mg/kg were not. A decrease in clearance and an increase in AUC of the sulfonamide also occurred at the low dose of curcuminoids (p<0.05). At 10 mg/kg, curcuminoids also inhibited the clearance of sulfamazathine which resulted in a significant increase of AUC (p<0.05), but not the elimination half-life of the drug.Note : The animals obtained curcuminoids 5 and 10 mg/kg of body weight orally, one hour prior to an injection of sulfamethazine (50 mg/kg of body weight) i.p. Blood sample (0.2-0.3 mL) were subsequently withdrawn from the tail vein at various time intervals and collected into heparinized tubes.
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : Curcumin (Cur)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : curcumin 0-20 micromolarDuration : -Type of interaction : PharmacodynamicsInteraction with drug : CelecoxibDose/Conc.(drug) : 0-40 micromolarResult : PositiveRemark :Note : Result: A synergistic effect was observed in inhibition of cell growth when the cells were exposed to various concentrations of celecoxib combined with curcumin. The inhibitory effect of the combination on cell growth was associated with an increased induction of apoptosis. The synergistic effect was mediated through a mechanism that involves inhibition of COX-2 activity. Data incomplete
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 10 micromolarDuration : -Type of interaction : Non-specifiedInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : -Result : PositiveRemark : Combining curcumin with 5-fluorouracil (5-FU) significantly increased growth inhibition of AGS cells compared with either curcumin or 5-FU alone (P<0.05).Note : Data incomplete.
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : 1 micromolarDuration : -Type of interaction : PharmacodynamicsInteraction with drug : Cyclophosphamide*/CPM/CTX/CYTDose/Conc.(drug) : -Result : NegativeRemark : Using an in vivo model of human breast cancer, dietary supplementation with curcumin was found to significantly inhibit cyclophosphamide-induced tumor regression. Such dietary supplementation was accompanied by a decrease in the activation of apoptosis by cyclophosphamide, as well as decreased the c-Jun NH2-terminal Kinase (JNK) activation.Note : Data incomplete.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : curcuminoidsType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : GemcitabineDose/Conc.(drug) : -Result : PositiveRemark : Results: In vivo, tumors from nude mice injected with pancreatic cancer cells and treated with a combination of curcumin and gemcitabine showed significant reductions in volume (P = 0.008 versus control; p = 0.036 versus gemcitabine alone), Ki-67 proliferation index (p = 0.030 versus control), NF-kappaB activation, and expression NF-kappaB-regulated gene products (cyclin D1, c-myc, Bcl-2, Bcl-xL, cellular inhibitor of apoptosis protein-1, cyclooxygenase-2, matrix metallopreteinase, and vascular endothelial growth factor) compared with tumors from control mice treated with olive oil only. The combination treatment was also highly effective in suppressing angiogenesis as indicated by a decrease in CD31(+) microvessel density (P = 0.018 versus control).Note : Data incomplete.
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 500 mg/kgDuration : -Type of interaction : Non-specifiedInteraction with drug : Docetaxel*/TaxotereDose/Conc.(drug) : -Result : PositiveRemark : In the SKOV3i.p.1 and Hey A8 in vivo models, curcumin alone resulted in 49% (P=0.08) and 55% (P=0.01) reduction in mean tumor growth compared with controls, whereas when combined with docetaxel elicited 96% (P<0.001) and 77% reductions in mean tumor growth compared with controls.Note : Data incomplete.
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 500 mg/kgDuration : -Type of interaction : Non-specifiedInteraction with drug : Docetaxel*/TaxotereDose/Conc.(drug) : -Result : PositiveRemark : In mice with multidrug-resistant Hey A8-MDR tumors, treatment with curcumin alone and combined with docetaxel resulted in significant 47% and 58% reduction in tumor growth, resp. (P=0.05).Note : Data incomplete.
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Docetaxel*/TaxotereDose/Conc.(drug) : -Result : PositiveRemark : In SKOV3i.p.1 and Hey A8 tumors, curcumin alone and with docetaxel decreased both proliferation (P<0.001) and microvessel d. (P<0.001) and increased tumor cell apoptosis (p<0.05).Note : Data incomplete.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : curcuminType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : -Result : PositiveRemark : The level of COX-2 protein expression was reduced almost 6-fold after combination treatment. The results demonstrate synergism between curcumim and 5-FU at higher doses against the human colon cancer cell line HT-29 which associated with the decreased expression of COX-2 protein.
