Part Used : เหง้า
Activity : CELL GROWTH INHIBITION EFFECT
Solvent/Active Compound : curcumin
Type of experiment : in vivo
Type of animal : mouse
N(Total) : -
N(Treatment) : -
Route : Intraperitoneal
Dose/Conc.(herb) : Intraperitoneal combinatorial curcumin (50 mg/kg) and oxaliplatin (25 mg/kg), thrice per week.
Duration : 22 days
Type of interaction : Pharmacodynamics
Interaction with drug : Oxaliplatin*/Diaminocyclohexane oxalatoplatinum/L-OHP
Dose/Conc.(drug) : -
Remark : Result: Combinatorial administration of curcumin and oxaliplatin evidently inhibited the growth of colorectal cancer in nude mice, which was significantly more effective than either agent alone.
Note : Administration of combined curcumin and oxaliplatin effectively suppressed colorectal carcinoma in vivo through inducing apoptosis and thus may provide an effective treatment for colorectal carcinoma.