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Part Used : เหง้าActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : curcuminoidsType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5 mg/kg of body weightDuration : -Type of interaction : PharmacokineticsInteraction with drug : Sulfamethazine*/Sulfadimidine/Sulfadimethyldiazine/SulfamezathineDose/Conc.(drug) : -Result : PositiveRemark : Results: Curcuminoids at 5 mg/kg were able to enhance significantly the absorption rate and peak concentration of sulfamethazine in blood (p<0.05), while those at 10 mg/kg were not. A decrease in clearance and an increase in AUC of the sulfonamide also occurred at the low dose of curcuminoids (p<0.05). At 10 mg/kg, curcuminoids also inhibited the clearance of sulfamazathine which resulted in a significant increase of AUC (p<0.05), but not the elimination half-life of the drug.Note : The animals obtained curcuminoids 5 and 10 mg/kg of body weight orally, one hour prior to an injection of sulfamethazine (50 mg/kg of body weight) i.p. Blood sample (0.2-0.3 mL) were subsequently withdrawn from the tail vein at various time intervals and collected into heparinized tubes.
Part Used : เหง้าActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : curcuminoidsType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mg/kg of body weightDuration : -Type of interaction : PharmacokineticsInteraction with drug : Sulfamethazine*/Sulfadimidine/Sulfadimethyldiazine/SulfamezathineDose/Conc.(drug) : -Result : PositiveRemark : Results: Curcuminoids at 5 mg/kg were able to enhance significantly the absorption rate and peak concentration of sulfamethazine in blood (p<0.05), while those at 10 mg/kg were not. A decrease in clearance and an increase in AUC of the sulfonamide also occurred at the low dose of curcuminoids (p<0.05). At 10 mg/kg, curcuminoids also inhibited the clearance of sulfamazathine which resulted in a significant increase of AUC (p<0.05), but not the elimination half-life of the drug.Note : The animals obtained curcuminoids 5 and 10 mg/kg of body weight orally, one hour prior to an injection of sulfamethazine (50 mg/kg of body weight) i.p. Blood sample (0.2-0.3 mL) were subsequently withdrawn from the tail vein at various time intervals and collected into heparinized tubes.
