ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ราก

Activity : DRUG INTERACTION

Solvent/Active Compound : Curcumin-475 mg capsule

Type of experiment : human

Type of animal : -

Type of study : Open trial

N(Total) : 8

N(Treatment) : 8

Sex : -

Age : 32 - 38 yrs.

Route : Oral administration

Dose/Conc.(herb) : curcumin-475mg capsules/day

Duration : Following the administration of Daonil-5 mg, blood samples (1 mL) were collected from the patients at 0.5, 1, 2, 3, 4, 6, 8, 12 and 24h. Patients were treated with curcumin-475mg capsules for the next 10 consecutive days, one capsule per day. During treatment period, patients received both curcumin and Daonil. On the 11th day of the study following the administration of curcumin along with Daonil 5 mg, blood samples (1 mL) were collected once again at 0.5, 1, 2, 3, 4, 6, 8, 12 and 24 h.

Type of interaction : P.Kinetics & P.Dynamics

Interaction with drug : Daonil*/Glyburide/Glibenclamide/Diadeta/Glybenclamide/Glybenzcyclamide

Dose/Conc.(drug) : -

Result : Positive

Remark : Result: Glyburide concentrations changed at the second hour, Cmax was unchanged, the glucose levels were decreased, Area Under first Movement Curre (AUMC) was increased significantly, and no patient has experienced the hypoglycaemia. The co-administration of curcumin capsules with glyburide may be beneficial to the patients in better glycaemic control.

Note : Subject total: Subjects were type-2 diabetic patients.

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