Part Used : เหง้า
Activity : P-GLYCOPROTEIN INHIBITION
Solvent/Active Compound : curcuminnoids (curcumin I, II, III)
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : -
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Vinblastine*/VLB
Dose/Conc.(drug) : -
Remark : Type of experiment: Human cervical arcinoma cell line (KB-V1).
Results: Treating the cells with non-toxic dose of curcuminnoids increased their sensitivity to vinblastine only in the P-gp expressing drug resistant cell line KB-V1; and curcumin I retained the drug in KB-V1 cells more effectively than curcumin II and III, repectively.