Part Used : -
Activity : DRUG INTERACTION
Solvent/Active Compound : -
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : -
Duration : -
Type of interaction : Pharmacodynamics
Interaction with drug : Sirolimus*/Rapamycin
Dose/Conc.(drug) : -
Remark : When curcumin was combined at concentrations of 1.25-2.5 micromolar with sirolimus at concentrations from 0.63 to 1.25 mg/ml the effects were synergistic. Combination of curcumin (1.25-2.5 micromolar) with sirolimus (5 nanogram/ml) showed additive effects.