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Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : curcuminType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Docetaxel*/TaxotereDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: Human lung cancer call line A549. Results: Curcumin and docetaxel inhibited cell growth with a dose-dependent manner against A549 cells. The IC50 of curcumin was 10.25+/-1.03 micromolars while the IC50 docetaxel was 4.26+/-0.51 nM against A549 cells and the IC50 of curcumin + docetaxel against A549 cells were 2.81 +/- 0.27 micromolars (curcumin) and 2.81 +/-0.34 nM (docetaxel), respectively. The combination of two drugs generated more cell death than the drugs used singly. The cell inhibition rate of ~ 40% was detected when exposed to the combination of curcumin (2 micromolars) and docetaxel (2 nM) while an inhibition rate of <10% or 20% was observed when cells were treated by the same dose of curcumin or docetaxel,respectively. More obviously, combinational treatment of 0.5 micromolars curcumin and 0.5 nM docetaxel induced a nearly 20% cell death while <5% cell death was observed when curcumin or docetaxel was administered at the same dose singly.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : curcuminType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntravenousDose/Conc.(herb) : 15 mg/kgDuration : 15 daysType of interaction : PharmacodynamicsInteraction with drug : Docetaxel*/TaxotereDose/Conc.(drug) : Docetaxel administered at dose of 10 mg/kg.Result : PositiveRemark : Results: The combination of curcumin and docetaxel inhibited the growth of tumor more effciently than single delivery of curcumin of curcumin (P = 0.01 vs. Doc). At the end of treatment, the relative tumor volume and tumor inhibition rate was 4.19+/-1.39 and 28.3%, which was the lowest among all the groups indicating the strongest tumor inhibition. Additionally, simultaneous administration of curcumin and docetaxel showed little toxicity to normal tissue including bone marrow and liver at the therapeutic doses.
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 500 mg/kgDuration : -Type of interaction : Non-specifiedInteraction with drug : Docetaxel*/TaxotereDose/Conc.(drug) : -Result : PositiveRemark : In the SKOV3i.p.1 and Hey A8 in vivo models, curcumin alone resulted in 49% (P=0.08) and 55% (P=0.01) reduction in mean tumor growth compared with controls, whereas when combined with docetaxel elicited 96% (P<0.001) and 77% reductions in mean tumor growth compared with controls.Note : Data incomplete.
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 500 mg/kgDuration : -Type of interaction : Non-specifiedInteraction with drug : Docetaxel*/TaxotereDose/Conc.(drug) : -Result : PositiveRemark : In mice with multidrug-resistant Hey A8-MDR tumors, treatment with curcumin alone and combined with docetaxel resulted in significant 47% and 58% reduction in tumor growth, resp. (P=0.05).Note : Data incomplete.
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Docetaxel*/TaxotereDose/Conc.(drug) : -Result : PositiveRemark : In SKOV3i.p.1 and Hey A8 tumors, curcumin alone and with docetaxel decreased both proliferation (P<0.001) and microvessel d. (P<0.001) and increased tumor cell apoptosis (p<0.05).Note : Data incomplete.
