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Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : 16-O-methylcafestolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5-500 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : 10 micromolar in phosphate bufferResult : PositiveRemark : In the initial solution, the warfarin - albumin complex is formed, and this is confirmed by the fact that after the addition of albumin, the warfarin emission is enhanced by about 70%. The fluorescence emission of warfarin is further increased upon the addition of the diterpenes in the low concentration range. This happens with both 16-O-methylcafestol and cafestol, despite the fact that their different effect on albumin tryptophan emission suggests a different mode of binding. This behavior as displace warfarin by competition in the binding site, rather than enhancing the affinity.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : cafestolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5-500 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : 10 micromolar in phosphate bufferResult : PositiveRemark : In the initial solution, the warfarin - albumin complex is formed, and this is confirmed by the fact that after the addition of albumin, the warfarin emission is enhanced by about 70%. The fluorescence emission of warfarin is further increased upon the addition of the diterpenes in the low concentration range. This happens with both 16-O-methylcafestol and cafestol, despite the fact that their different effect on albumin tryptophan emission suggests a different mode of binding. This behavior as displace warfarin by competition in the binding site, rather than enhancing the affinity.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : caffeinated coffeeType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : AtorvastatinDose/Conc.(drug) : 10 mg/kg/dayResult : PositiveRemark : Type of experiment: Rat received 3-day atorvastatin (ATV) (10 mg/kg/day) or water by oral gavage once daily. Drinking water was replaced by water + sugar (7.5 g/100 mL), caffeinated coffee (CC) with sugar, or decaffeinated coffee (DC) with sugar. Results: CC, but not DC, abrogated the infarct size-limiting effects of ATV by blocking the adenosine receptors and preventing the phosphorylation of Akt. CC did not affect infarct size in rats not receiving ATV.Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : decaffeinated coffeeType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : AtorvastatinDose/Conc.(drug) : 10 mg/kg/dayResult : PositiveRemark : Type of experiment: Rat received 3-day atorvastatin (ATV) (10 mg/kg/day) or water by oral gavage once daily. Drinking water was replaced by water + sugar (7.5 g/100 mL), caffeinated coffee (CC) with sugar, or decaffeinated coffee (DC) with sugar. Results: CC, but not DC, abrogated the infarct size-limiting effects of ATV by blocking the adenosine receptors and preventing the phosphorylation of Akt. CC did not affect infarct size in rats not receiving ATV.Note : Data incomplete
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Antipyrine*/PhenazoneDose/Conc.(drug) : -Result : PositiveRemark :Note : Data incomplete Result: The consumption of tobacco, alc., coffee, and tea, the age, and the sex correlated with the antipyrine clearance.
