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Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : atorvastatin (5 mg/kg) + garlic (0.5% w/w)Duration : 12 weeksType of interaction : PharmacokineticsInteraction with drug : AtorvastatinDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Results: The study revealed higher values [C(max), AUC, Area Under The Moment Curve (AUMC), mean resident time (MRT), and half-life] of atorvastatin in garlic-treated groups.Note : Type of experiment: Rats with induced dyslipidemia were divided into five groups. Group 1 was given atorvastatin (10 mg/kg body weight (b. wt) orally), group 2 was given atorvastain (10 mg/kg b.wt orally)+garlic (1% w/w in feed), group 3 was maintained on atorvastatin (5 mg/kg b.wt orally)+garlic (0.5% w/w in feed), group 4 was maintained on atorvastain (7.5 mg/kg b.wt orally)+garlic (0.25% w/w in feed), and group 5 was maintained on atorvastatin (2.5 mg/kg b.wt orally)+garlic (0.75% w/w in feed).
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : atorvastatin (7.5 mg/kg) + garlic (0.25% w/w)Duration : 12 weeksType of interaction : PharmacokineticsInteraction with drug : AtorvastatinDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Results: The study revealed higher values [C(max), AUC, Area Under The Moment Curve (AUMC), mean resident time (MRT), and half-life] of atorvastatin in garlic-treated groups.Note : Type of experiment: Rats with induced dyslipidemia were divided into five groups. Group 1 was given atorvastatin (10 mg/kg body weight (b. wt) orally), group 2 was given atorvastain (10 mg/kg b.wt orally)+garlic (1% w/w in feed), group 3 was maintained on atorvastatin (5 mg/kg b.wt orally)+garlic (0.5% w/w in feed), group 4 was maintained on atorvastain (7.5 mg/kg b.wt orally)+garlic (0.25% w/w in feed), and group 5 was maintained on atorvastatin (2.5 mg/kg b.wt orally)+garlic (0.75% w/w in feed).
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : atorvastatin (2.5 mg/kg) + garlic (0.75% w/w)Duration : 12 weeksType of interaction : PharmacokineticsInteraction with drug : AtorvastatinDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Results: The study revealed higher values [C(max), AUC, Area Under The Moment Curve (AUMC), mean resident time (MRT), and half-life] of atorvastatin in garlic-treated groups.Note : Type of experiment: Rats with induced dyslipidemia were divided into five groups. Group 1 was given atorvastatin (10 mg/kg body weight (b. wt) orally), group 2 was given atorvastain (10 mg/kg b.wt orally)+garlic (1% w/w in feed), group 3 was maintained on atorvastatin (5 mg/kg b.wt orally)+garlic (0.5% w/w in feed), group 4 was maintained on atorvastain (7.5 mg/kg b.wt orally)+garlic (0.25% w/w in feed), and group 5 was maintained on atorvastatin (2.5 mg/kg b.wt orally)+garlic (0.75% w/w in feed).
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : aged garlic extract (AGE)Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : AGE 100 mg/kgDuration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : NaltrexoneDose/Conc.(drug) : 0.5 mg/kg, i.p.Result : PositiveRemark : Results: The mice who received AGE+NTX had significantly longer survival time compared with the mice treated with AGE or NTX alone. An enhanced inhibitory effect on tumor growth was seen in combination therapy group. The CD4+/CD8+ ratio and in vitro lFN-gamma production of splenocytes were significantly increased in AGE+NTX and NTX groups. WEHl-164 spectific cytotoxicity of splenocytes was also significantly increased at 25:1 E:T ratio in AGE+NTX treated mice. Coadministration of AGE with NTX resulted in improvement of immune responses against experimentally implanted fibrosarcoma tumors in BALB/c mice.Note : Type of experiment: BALB/c mice at 6-8 weeks of age went under experimental induction of tumor by injection of WEHl-164 cells. Tumorized mice were randomly divided into 4 groups, the first group received aged garlic extract (AGE), the second group received naltrexone (NTX), the third group received both of them, and the fourth group (the control or PBS group) received only phosphated buffered saline (PBS).
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : diallyl sulfide and diallyl trisulfideType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Daunorubicin*/Daunomycin/RubidomycinDose/Conc.(drug) : -Result : NegativeRemark : Sulforaphane, indole-3-carbinol, and diallyl sulfide and diallyl trisulfide had no effect on P-glycoprotein.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 233N(Treatment) : -Sex : FemaleAge : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Tamoxifen*/TAMDose/Conc.(drug) : -Result : PositiveRemark : The study identified use of 35 different typed of complimentary alternative medicine products and seven of these could potentially increase the risk of breast cancer or interact with tamoxifen or aromatase inhibitiors: soy, garlic, Ginkgo biloba, Echinacea, ginseng, velerian and phytoestrogens (excluding soy).Note : Data incomplete Subject were consecutive breast cancer patients
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Garlic homogenate (GH)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 250 mg/kgDuration : 30 daysType of interaction : PharmacodynamicsInteraction with drug : DiltiazemDose/Conc.(drug) :Result : PositiveRemark : Administration of GH resulted in decrease in LDH and CK-MB activities in serum and increase in heart tissue homogenate (HTH) compared to isoproterenol (ISO) control. The superoxide dismutase and catalase acitivities were found to be increased in all treated groups compared to ISO control. The QRS duration, QT segment and RR intervals were normalized by GH and calcium channel blockers (CCBs) treatments. Among the various combinations, GH 250 mg/kg with diltiazem was substantially more portective than GH with nifedipine/verapamil thereby providing strength to myocardium during stress.Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Garlic homogenate (GH)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 500 mg/kgDuration : 30 daysType of interaction : PharmacodynamicsInteraction with drug : DiltiazemDose/Conc.(drug) :Result : PositiveRemark : Administration of GH resulted in decrease in LDH and CK-MB activities in serum and increase in heart tissue homogenate (HTH) compared to isoproterenol (ISO) control. The superoxide dismutase and catalase acitivities were found to be increased in all treated groups compared to ISO control. The QRS duration, QT segment and RR intervals were normalized by GH and calcium channel blockers (CCBs) treatments. Among the various combinations, GH 250 mg/kg with diltiazem was substantially more portective than GH with nifedipine/verapamil thereby providing strength to myocardium during stress.Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Garlic homogenate (GH)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 250 mg/kgDuration : 30 daysType of interaction : PharmacodynamicsInteraction with drug : NifedipineDose/Conc.(drug) :Result : PositiveRemark : Administration of GH resulted in decrease in LDH and CK-MB activities in serum and increase in heart tissue homogenate (HTH) compared to isoproterenol (ISO) control. The superoxide dismutase and catalase acitivities were found to be increased in all treated groups compared to ISO control. The QRS duration, QT segment and RR intervals were normalized by GH and calcium channel blockers (CCBs) treatments. Among the various combinations, GH 250 mg/kg with diltiazem was substantially more portective than GH with nifedipine/verapamil thereby providing strength to myocardium during stress.Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Garlic homogenate (GH)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 500 mg/kgDuration : 30 daysType of interaction : PharmacodynamicsInteraction with drug : NifedipineDose/Conc.(drug) :Result : PositiveRemark : Administration of GH resulted in decrease in LDH and CK-MB activities in serum and increase in heart tissue homogenate (HTH) compared to isoproterenol (ISO) control. The superoxide dismutase and catalase acitivities were found to be increased in all treated groups compared to ISO control. The QRS duration, QT segment and RR intervals were normalized by GH and calcium channel blockers (CCBs) treatments. Among the various combinations, GH 250 mg/kg with diltiazem was substantially more portective than GH with nifedipine/verapamil thereby providing strength to myocardium during stress.Note : Data incomplete
