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Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : diallyl trisulfide (DATS)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : OtherDose/Conc.(herb) : 20 mg/kgDuration : 5 min before the i.v. administration or oral gavage of nifedipineType of interaction : PharmacokineticsInteraction with drug : NifedipineDose/Conc.(drug) : 0.75 mg/kg, i.v. or 3 mg/kg, oralResult : PositiveRemark : Type of experiment: In the short-term on nifedipine, vehicle (medium chain triglycerides) or DATS (20 mg/kg) was intragastically administered 5 min before the i.v. administration (0.75 mg/kg) or oral gavage of nifedipine (3 mg/kg).Note : Compared to the control groups, higher Cmax and AUC0-24h were observed for oral gavage of nifedipine after short-term and long-term pretreatment of DATS, whereas those for intravenous nifedipine were little changed. The oral bioavailabilities of nifedipine were remarkably enhnaced via the concomitant use of DATS.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : diallyl trisulfide (DATS)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : OtherDose/Conc.(herb) : 20 mg/kgDuration : 15 daysType of interaction : PharmacokineticsInteraction with drug : NifedipineDose/Conc.(drug) : 0.75 mg/kg, i.v. or 3 mg/kg, oralResult : PositiveRemark : Type of experiment: In long-term administration groups, rats were gavaged once daily for 15 consecutive days with either medium-chain triglycerides (control) or 20 mg/kg DATS in a volume of 2.5 mL/kg. On the morning of day 15, all the animals were gastrogavaged with nifedipine (3 mg/kg) or intravenously administered nifedipine (0.75 mg/kg solution) 5 min after the last administration of DATS.Note : Compared to the control groups, higher Cmax and AUC0-24h were observed for oral gavage of nifedipine after short-term and long-term pretreatment of DATS, whereas those for intravenous nifedipine were little changed. The oral bioavailabilities of nifedipine were remarkably enhnaced via the concomitant use of DATS.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : garlic homogenateType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 125 mg/kg bw.Duration : 3 weeksType of interaction : P.Kinetics & P.DynamicsInteraction with drug : Hydrochlorothiazide*/HCTZDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Results: garlic in moderate dose (250 mg/kg) with added HCTZ possesses synergistic cardioprotective and antihypertensive properties against frutose- and isoproterenol-induced toxicities.Note : Experiment: Female Wistar albino rats were divided into nine groups. Group I: normal control, given ordinary drinking water, group II: fructose-fed (HF), group III: fructose plus hydrochlorothiazide (HCTZ) (10 mg/kg, p.o.) in the 6th week, group IV, V and VI were fed with fructose plus garlic homogenate (GH) 125, 250 and 500 mg/kg respectively orally for 3 weeks, group VII, VIII and IX were continued with fructose plus GH 125, 250 and 500 mg/kg respectively orally for 3 weeks as well as HCTZ (10 mg/kg, p.o.) in the 6th week. At the end of treatment, animals of all groups except group I were administered isoproterenol (ISO; 175 mg/kg s.c.) for 2 consecutive days.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : garlic homogenateType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 250 mg/kg bw.Duration : 3 weeksType of interaction : P.Kinetics & P.DynamicsInteraction with drug : Hydrochlorothiazide*/HCTZDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Results: garlic in moderate dose (250 mg/kg) with added HCTZ possesses synergistic cardioprotective and antihypertensive properties against frutose- and isoproterenol-induced toxicities.Note : Experiment: Female Wistar albino rats were divided into nine groups. Group I: normal control, given ordinary drinking water, group II: fructose-fed (HF), group III: fructose plus hydrochlorothiazide (HCTZ) (10 mg/kg, p.o.) in the 6th week, group IV, V and VI were fed with fructose plus garlic homogenate (GH) 125, 250 and 500 mg/kg respectively orally for 3 weeks, group VII, VIII and IX were continued with fructose plus GH 125, 250 and 500 mg/kg respectively orally for 3 weeks as well as HCTZ (10 mg/kg, p.o.) in the 6th week. At the end of treatment, animals of all groups except group I were administered isoproterenol (ISO; 175 mg/kg s.c.) for 2 consecutive days.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : garlic homogenateType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 500 mg/kg bw.Duration : 3 weeksType of interaction : P.Kinetics & P.DynamicsInteraction with drug : Hydrochlorothiazide*/HCTZDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Results: garlic in moderate dose (250 mg/kg) with added HCTZ possesses synergistic cardioprotective and antihypertensive properties against frutose- and isoproterenol-induced toxicities.Note : Experiment: Female Wistar albino rats were divided into nine groups. Group I: normal control, given ordinary drinking water, group II: fructose-fed (HF), group III: fructose plus hydrochlorothiazide (HCTZ) (10 mg/kg, p.o.) in the 6th week, group IV, V and VI were fed with fructose plus garlic homogenate (GH) 125, 250 and 500 mg/kg respectively orally for 3 weeks, group VII, VIII and IX were continued with fructose plus GH 125, 250 and 500 mg/kg respectively orally for 3 weeks as well as HCTZ (10 mg/kg, p.o.) in the 6th week. At the end of treatment, animals of all groups except group I were administered isoproterenol (ISO; 175 mg/kg s.c.) for 2 consecutive days.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : fresh garlic extract (FGE)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : FGE 15-180 mg/mlDuration : 24 h of incubation at 37 degress celsiusType of interaction : PharmacodynamicsInteraction with drug : AmpicillinDose/Conc.(drug) : -Result : PositiveRemark : Results: Maximum incorporation of 90 mg/ml of FGE with 24 micrograms/ml of ampicillin was use. Synergistic interaction was observed by the combination of FGE with ampicillin for all the strains of S. aureus. Mean minimum inhibitor concentration (MIC) of ampicillin per se was 24 micrograms/ml. Addition of 30-60 mg/ml of FGE reduced MIC of ampicillin to <2 micrograms/ml.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : Aged garlic extractType of experiment : humanType of animal : -Type of study : Case-controlN(Total) : 10N(Treatment) : 10Sex : -Age : 45.32+/-7.96 yrs.Route : Oral administrationDose/Conc.(herb) : 600 mg/dayDuration : 7 daysType of interaction : PharmacodynamicsInteraction with drug : CelecoxibDose/Conc.(drug) : 10 mg/dayResult : NegativeRemark : Results: coadministration of garlic and cilostazol in single and multiple doses for seven days did not produce any significant change in the antiplatelet activity of the individual drugs.Note : Subject total: Type ll diabetic patients. After an overnight fast and 12 hours after the last antidiabetic medication dose, subjects were randomized in a 4-way crossover design to receive either 600 mg of garlic, 100 mg of cilostazol, 600 mg garlic + 100 mg cilostazol, or placebo, once daily for 7 days as per the randomization table. Blood samples for platelet aggregation were taken immediately before (0 hours) and 2, 4, and 6 hours after the drug treatment on first day.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : Aged garlic extractType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 10N(Treatment) : 10Sex : -Age : 45.32+/-7.96 yrs.Route : Oral administrationDose/Conc.(herb) : 600 mg/dayDuration : 7 daysType of interaction : PharmacodynamicsInteraction with drug : CelecoxibDose/Conc.(drug) : 10 mg/dayResult : NegativeRemark : Results: coadministration of garlic and cilostazol in single and multiple doses for seven days did not produce any significant change in the antiplatelet activity of the individual drugs.Note : Subject total: Type ll diabetic patients. After an overnight fast and 12 hours after the last antidiabetic medication dose, subjects were randomized in a 4-way crossover design to receive either 600 mg of garlic, 100 mg of cilostazol, 600 mg garlic + 100 mg cilostazol, or placebo, once daily for 7 days as per the randomization table. Blood samples for platelet aggregation were taken immediately before (0 hours) and 2, 4, and 6 hours after the drug treatment on first day.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : Aged garlic extractType of experiment : humanType of animal : -Type of study : Cross overN(Total) : 10N(Treatment) : 10Sex : -Age : 45.32+/-7.96 yrs.Route : Oral administrationDose/Conc.(herb) : 600 mg/dayDuration : 7 daysType of interaction : PharmacodynamicsInteraction with drug : CelecoxibDose/Conc.(drug) : 10 mg/dayResult : NegativeRemark : Results: coadministration of garlic and cilostazol in single and multiple doses for seven days did not produce any significant change in the antiplatelet activity of the individual drugs.Note : Subject total: Type ll diabetic patients. After an overnight fast and 12 hours after the last antidiabetic medication dose, subjects were randomized in a 4-way crossover design to receive either 600 mg of garlic, 100 mg of cilostazol, 600 mg garlic + 100 mg cilostazol, or placebo, once daily for 7 days as per the randomization table. Blood samples for platelet aggregation were taken immediately before (0 hours) and 2, 4, and 6 hours after the drug treatment on first day.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : atorvastatin (10 mg/kg) + garlic (1% w/w)Duration : 12 weeksType of interaction : PharmacokineticsInteraction with drug : AtorvastatinDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Results: The study revealed higher values [C(max), AUC, Area Under The Moment Curve (AUMC), mean resident time (MRT), and half-life] of atorvastatin in garlic-treated groups.Note : Type of experiment: Rats with induced dyslipidemia were divided into five groups. Group 1 was given atorvastatin (10 mg/kg body weight (b. wt) orally), group 2 was given atorvastain (10 mg/kg b.wt orally)+garlic (1% w/w in feed), group 3 was maintained on atorvastatin (5 mg/kg b.wt orally)+garlic (0.5% w/w in feed), group 4 was maintained on atorvastain (7.5 mg/kg b.wt orally)+garlic (0.25% w/w in feed), and group 5 was maintained on atorvastatin (2.5 mg/kg b.wt orally)+garlic (0.75% w/w in feed).
