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| Thai / English name |
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 1818N(Treatment) : 25Sex : Both sexAge : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : In a recent cross -sectional point - of - care survey of 1818 patients, 25 cases involving coadministered warfarin/antiplatelet agent and garlic identified a potential clinically significant interaction between the anticoagulant/platelets and garlic.Note : Data incomplete, data from review article
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case reportN(Total) : 2N(Treatment) : 2Sex : Both sexAge : -Route : Oral administrationDose/Conc.(herb) : -Duration : > 2 weeksType of interaction : PharmacokineticsInteraction with drug : RitonavirDose/Conc.(drug) : 400 mg twice dailyResult : PositiveRemark : A two HIV - infected patients taking garlic supplements for > 2 weeks reveals the development of severe gastrointestinal toxicity after the initiation of ritonavir - containing antiretroviral therapy (400 or 600 mg twice daily). Moreover, these symptoms resolved after discontinuing garlic or ritonavir. This occurrence was not likely related to increased systemic concentrations of ritonavir. In addition, gastrointestinal symptoms recurred during rechallenge with low - dose ritonavir (100 mg twice daily) in the presence of garlic.Note : Data incomplete, data from review article
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case reportN(Total) : 2N(Treatment) : 2Sex : Both sexAge : -Route : Oral administrationDose/Conc.(herb) : -Duration : > 2 weeksType of interaction : PharmacokineticsInteraction with drug : RitonavirDose/Conc.(drug) : 600 mg twice dailyResult : PositiveRemark : A two HIV - infected patients taking garlic supplements for > 2 weeks reveals the development of severe gastrointestinal toxicity after the initiation of ritonavir - containing antiretroviral therapy (400 or 600 mg twice daily). Moreover, these symptoms resolved after discontinuing garlic or ritonavir. This occurrence was not likely related to increased systemic concentrations of ritonavir. In addition, gastrointestinal symptoms recurred during rechallenge with low - dose ritonavir (100 mg twice daily) in the presence of garlic.Note : Data incomplete, data from review article
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : FemaleAge : -Route : Oral administrationDose/Conc.(herb) : a curry containing garlic and bitter melonDuration : -Type of interaction : PharmacodynamicsInteraction with drug : ChlorpropamideDose/Conc.(drug) : -Result : PositiveRemark : Garlic may also enhance the effect of antidiabetic drugs such as chlorpropamide. It was reported that a woman on chlorpropamide therapy who ate a curry containing garlic and Momordica charantia experienced an enhanced antidiabetic response.Note : Data incomplete, data from review article
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : aged garlic extractType of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 16N(Treatment) : 16Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : aged garlic extract (equivalent to 6-7 cloves of garlic)Duration : 3 monthsType of interaction : PharmacodynamicsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : 1 gram orallyResult : NegativeRemark : A clinical trial of healthy volunteers being administered commercial aged garlic extract (approximately equivalent to six to seven cloves of garlic) for 3 months did not alter the oxidative and glucuronidation metabolism of acetaminophen (1 g orally) but caused a slight increase in sulfation.Note : Data incomplete, data from review article
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : diallyl sulfoneType of experiment : in vivoType of animal : mouseType of study : -N(Total) :N(Treatment) :Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) :Result : PositiveRemark : An animal study in mice indicated that garlic - derived diallyl sulfone (DASO2) decreased the plsma concentrations of oxidative acetaminophen metabolites but not of nonoxidative acetaminophen metabolites, due to the inhibition of CYP2E1, which is the major enzyme responsible for the bioactivation of acetaminophen.Note : Data incomplete, data from review article
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : diallyl sulfoneType of experiment : in vivoType of animal : mouseType of study : -N(Total) :N(Treatment) :Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 25 mg/kgDuration : 1 h prior to acetaminophen administrationType of interaction : PharmacodynamicsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : -Result : PositiveRemark : Diallyl sulfone (25 mg/kg), when administered orally 1 h prior to, immediately, or 20 min after a toxic dose of acetaminophen, completely protected mice from the development of hepatotoxicity. A low dose of diallyl sulfone (5 mg/kg), when administered to mice 1 h prior to acetaminophen administration, showed protective effects.Note : Data incomplete, data from review article
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : diallyl sulfoneType of experiment : in vivoType of animal : mouseType of study : -N(Total) :N(Treatment) :Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 25 mg/kgDuration : immediately to acetaminophen administrationType of interaction : PharmacodynamicsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : -Result : PositiveRemark : Diallyl sulfone (25 mg/kg), when administered orally 1 h prior to, immediately, or 20 min after a toxic dose of acetaminophen, completely protected mice from the development of hepatotoxicity. A low dose of diallyl sulfone (5 mg/kg), when administered to mice 1 h prior to acetaminophen administration, showed protective effects.Note : Data incomplete, data from review article
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : diallyl sulfoneType of experiment : in vivoType of animal : mouseType of study : -N(Total) :N(Treatment) :Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 25 mg/kgDuration : 20 min after acetaminophen administrationType of interaction : PharmacodynamicsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : -Result : PositiveRemark : Diallyl sulfone (25 mg/kg), when administered orally 1 h prior to, immediately, or 20 min after a toxic dose of acetaminophen, completely protected mice from the development of hepatotoxicity. A low dose of diallyl sulfone (5 mg/kg), when administered to mice 1 h prior to acetaminophen administration, showed protective effects.Note : Data incomplete, data from review article
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : diallyl sulfoneType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5 mg/kgDuration : 1 h prior to acetaminophen administrationType of interaction : PharmacodynamicsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : -Result : PositiveRemark : Diallyl sulfone (25 mg/kg), when administered orally 1 h prior to, immediately, or 20 min after a toxic dose of acetaminophen, completely protected mice from the development of hepatotoxicity. A low dose of diallyl sulfone (5 mg/kg), when administered to mice 1 h prior to acetaminophen administration, showed protective effects.Note : Data incomplete, data from review article
