| Synonym |
| Thai / English name |
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : 80% MethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Dose in 5.3 L**Duration : -Type of interaction : PharmacokineticsInteraction with drug : Serotonin*/5-hydroxytryptamine/5-HTDose/Conc.(drug) : 80 mMResult : NegativeRemark : Results: data points did not fit the IC50 curve.Note : Type of experiment: *Human liver microsomal (HLM) **Working solutions were freshly prepared so that final herbal concentrations in screening incubations would represent the recommended daily intake of each extract in 53, 5.3, and 0.53 liters. Each herbal extract was coincubated at three concentrations with trifluoperazine (for UGT1A4), serotonin (for UGT1A6), and mycophenolic acid (for UGT1A9) and human liver microsome. Formation of trifluoperezine glucoronide, serotonin glucuronide, and mycophenolic acid beta-D- glucoronide were used as index reactions for activity of UGT1A4, UGT1A6, and UGT1A9 enzyme activities, respectively.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : 80% MethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Dose in 0.53 L**Duration : -Type of interaction : PharmacokineticsInteraction with drug : Serotonin*/5-hydroxytryptamine/5-HTDose/Conc.(drug) : 80 mMResult : NegativeRemark : Results: data points did not fit the IC50 curve.Note : Type of experiment: *Human liver microsomal (HLM) **Working solutions were freshly prepared so that final herbal concentrations in screening incubations would represent the recommended daily intake of each extract in 53, 5.3, and 0.53 liters. Each herbal extract was coincubated at three concentrations with trifluoperazine (for UGT1A4), serotonin (for UGT1A6), and mycophenolic acid (for UGT1A9) and human liver microsome. Formation of trifluoperezine glucoronide, serotonin glucuronide, and mycophenolic acid beta-D- glucoronide were used as index reactions for activity of UGT1A4, UGT1A6, and UGT1A9 enzyme activities, respectively.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : 80% MethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Dose in 53 L**Duration : -Type of interaction : PharmacokineticsInteraction with drug : Mycophenolic acid*/Mycophenolate/MMF/MPA/MofetilDose/Conc.(drug) : 240 micromolarResult : NegativeRemark : Results: data points did not fit the IC50 curve.Note : Type of experiment: *Human liver microsomal (HLM) **Working solutions were freshly prepared so that final herbal concentrations in screening incubations would represent the recommended daily intake of each extract in 53, 5.3, and 0.53 liters. Each herbal extract was coincubated at three concentrations with trifluoperazine (for UGT1A4), serotonin (for UGT1A6), and mycophenolic acid (for UGT1A9) and human liver microsome. Formation of trifluoperezine glucoronide, serotonin glucuronide, and mycophenolic acid beta-D- glucoronide were used as index reactions for activity of UGT1A4, UGT1A6, and UGT1A9 enzyme activities, respectively.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : 80% MethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Dose in 5.3 L**Duration : -Type of interaction : PharmacokineticsInteraction with drug : Mycophenolic acid*/Mycophenolate/MMF/MPA/MofetilDose/Conc.(drug) : 240 micromolarResult : NegativeRemark : Results: data points did not fit the IC50 curve.Note : Type of experiment: *Human liver microsomal (HLM) **Working solutions were freshly prepared so that final herbal concentrations in screening incubations would represent the recommended daily intake of each extract in 53, 5.3, and 0.53 liters. Each herbal extract was coincubated at three concentrations with trifluoperazine (for UGT1A4), serotonin (for UGT1A6), and mycophenolic acid (for UGT1A9) and human liver microsome. Formation of trifluoperezine glucoronide, serotonin glucuronide, and mycophenolic acid beta-D- glucoronide were used as index reactions for activity of UGT1A4, UGT1A6, and UGT1A9 enzyme activities, respectively.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : 80% MethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Dose in 0.53 L**Duration : -Type of interaction : PharmacokineticsInteraction with drug : Mycophenolic acid*/Mycophenolate/MMF/MPA/MofetilDose/Conc.(drug) : 240 micromolarResult : NegativeRemark : Results: data points did not fit the IC50 curve.Note : Type of experiment: *Human liver microsomal (HLM) **Working solutions were freshly prepared so that final herbal concentrations in screening incubations would represent the recommended daily intake of each extract in 53, 5.3, and 0.53 liters. Each herbal extract was coincubated at three concentrations with trifluoperazine (for UGT1A4), serotonin (for UGT1A6), and mycophenolic acid (for UGT1A9) and human liver microsome. Formation of trifluoperezine glucoronide, serotonin glucuronide, and mycophenolic acid beta-D- glucoronide were used as index reactions for activity of UGT1A4, UGT1A6, and UGT1A9 enzyme activities, respectively.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 250N(Treatment) : 201Sex : Both sexAge : 69+/-10 yrs.Route : Oral administrationDose/Conc.(herb) : Consumption of herbs at least 4 times per weekDuration : -Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : Consumption of herbs at least 4 times per week was associated with suboptimal anticoagulation control with warfarin. Patients treated with warfarin should not only be aware of the intake of herbal drugs but also of foods with herbal ingredients such as garlic, ginger, and papaya.Note : Patients with atrial fibrillation (AF) who were prescribed warfarin therapy for at least 6 months before the study were recruited from the medical and cardiac clinics.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1 ml of garlic extract containing 1.14 g of garlic extract as low doseDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The oral administration of onion and garlic led to a significant depression, in the serum levels of the thyroid hormones, T3 and T4. This depression could have been made possible by the competitive displacement of iodide ions in the thyroid follicle by the sulphide derivatives present in onion and garlic. Supplementation with iodine did not improve the level serum thyroid hormones but further led to more depression.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1.5 ml of garlic extract containing 1.7 g of garlic extract as high doseDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The oral administration of onion and garlic led to a significant depression, in the serum levels of the thyroid hormones, T3 and T4. This depression could have been made possible by the competitive displacement of iodide ions in the thyroid follicle by the sulphide derivatives present in onion and garlic. Supplementation with iodine did not improve the level serum thyroid hormones but further led to more depression.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1 ml of garlic extract containing 1.14 g of garlic extract as low dose + potassium iodine solutionDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The oral administration of onion and garlic led to a significant depression, in the serum levels of the thyroid hormones, T3 and T4. This depression could have been made possible by the competitive displacement of iodide ions in the thyroid follicle by the sulphide derivatives present in onion and garlic. Supplementation with iodine did not improve the level serum thyroid hormones but further led to more depression.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1.5 ml of garlic extract containing 1.7 g of garlic extract as low dose + potassium iodine solutionDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The oral administration of onion and garlic led to a significant depression, in the serum levels of the thyroid hormones, T3 and T4. This depression could have been made possible by the competitive displacement of iodide ions in the thyroid follicle by the sulphide derivatives present in onion and garlic. Supplementation with iodine did not improve the level serum thyroid hormones but further led to more depression.
