| Synonym |
| Thai / English name |
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : non specifiedType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : SaquinavirDose/Conc.(drug) : -Result : PositiveRemark : Reduction of CYP2E1 activity in humans and some animal species; no increase in CYP2B1/2 in humans. Mild inhibition of Pgp in vitro. Single reports of increased bleeding time with lisinopril, warfarin. Reduces bioavailability of the protease inhibitor saquinavir and to a lesser extent ritonavir. Appears safe with most drugs except saquinavir.Note : Data from review, data incomplete.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : non specifiedType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : RitonavirDose/Conc.(drug) : -Result : PositiveRemark : Reduction of CYP2E1 activity in humans and some animal species; no increase in CYP2B1/2 in humans. Mild inhibition of Pgp in vitro. Single reports of increased bleeding time with lisinopril, warfarin. Reduces bioavailability of the protease inhibitor saquinavir and to a lesser extent ritonavir. Appears safe with most drugs except saquinavir.Note : Data from review, data incomplete.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Allicin, gamma-glutamyl-(s)-ally-L-CysteineType of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 354* (M/F=114/240)N(Treatment) : 3 of 29Sex : Both sexAge : The majorities (40.1%) of the respondents' were between 35-44 yrs.Route : Oral administrationDose/Conc.(herb) : Half cup/glass (6.9%), 1 cup/glass (6.9%), 1-2 spoonful (10.3%) (data analyzed from 29 of 354 patients who used herbal drugs)Duration : Once daily (58.6%), many times daily (6.9%), weekly (10.3%), occasionally (24.1%) (data analyzed from 29 of 354 patients who used herbal drugs)Type of interaction : PharmacodynamicsInteraction with drug : Zidovudine*/AZT/ZDV/AzidothymidineDose/Conc.(drug) : -Result : PositiveRemark :Note : *Subject total: Subjects were HIV patients. **Subject treatment: 29 of 354 patients used herbal drugs. Result: A marginal improvement though not significant (p>/=0.05) in the CD4 counts (489.8+/-195.2; 419.1+/-236.2) and viral load (5117.8+/-26092.0;31136.7+/-197954.6) of HIV patients on herbal drugs compared to those who are not on herbal drugs. There are no significant associations (p>/=0.05) between socio-demographic data and use of herbal medicine. However, there is a significant difference (p
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Allicin, gamma-glutamyl-(s)-ally-L-CysteineType of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 354* (M/F=114/240)N(Treatment) : 3 of 29Sex : Both sexAge : The majorities (40.1%) of the respondents' were between 35-44 yrs.Route : Oral administrationDose/Conc.(herb) : Half cup/glass (6.9%), 1 cup/glass (6.9%), 1-2 spoonful (10.3%) (data analyzed from 29 of 354 patients who used herbal drugs)Duration : Once daily (58.6%), many times daily (6.9%), weekly (10.3%), occasionally (24.1%) (data analyzed from 29 of 354 patients who used herbal drugs)Type of interaction : PharmacodynamicsInteraction with drug : Lamivudine*/3TCDose/Conc.(drug) : -Result : PositiveRemark :Note : *Subject total: Subjects were HIV patients. **Subject treatment: 29 of 354 patients used herbal drugs. Result: A marginal improvement though not significant (p>/=0.05) in the CD4 counts (489.8+/-195.2; 419.1+/-236.2) and viral load (5117.8+/-26092.0;31136.7+/-197954.6) of HIV patients on herbal drugs compared to those who are not on herbal drugs. There are no significant associations (p>/=0.05) between socio-demographic data and use of herbal medicine. However, there is a significant difference (p
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Allicin, gamma-glutamyl-(s)-ally-L-CysteineType of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 354* (M/F=114/240)N(Treatment) : 3 of 29Sex : Both sexAge : The majorities (40.1%) of the respondents' were between 35-44 yrs.Route : Oral administrationDose/Conc.(herb) : Half cup/glass (6.9%), 1 cup/glass (6.9%), 1-2 spoonful (10.3%) (data analyzed from 29 of 354 patients who used herbal drugs)Duration : Once daily (58.6%), many times daily (6.9%), weekly (10.3%), occasionally (24.1%) (data analyzed from 29 of 354 patients who used herbal drugs)Type of interaction : PharmacodynamicsInteraction with drug : NevirapineDose/Conc.(drug) : -Result : PositiveRemark :Note : *Subject total: Subjects were HIV patients. **Subject treatment: 29 of 354 patients used herbal drugs. Result: A marginal improvement though not significant (p>/=0.05) in the CD4 counts (489.8+/-195.2; 419.1+/-236.2) and viral load (5117.8+/-26092.0;31136.7+/-197954.6) of HIV patients on herbal drugs compared to those who are not on herbal drugs. There are no significant associations (p>/=0.05) between socio-demographic data and use of herbal medicine. However, there is a significant difference (p
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : 80% ethanol extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mg/kgDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : EzetimibeDose/Conc.(drug) : 30 microgram/kgResult : PositiveRemark : The combination of ezetimibe with garlic extract resulted in lowering of serum total body cholesterol, triglycerides, LDL-cholesterol, VLDL-cholesterol along with increase in serum HDL-cholesterol after treatment.Note : The animals were randomly divided into seven groups, six animals each. The dosage regimen was as follows: Group I-control, II-fructose (5 g/kg), III-fructose and ezetimibe, IV-fructose and garlic extract, V-fructose, Ezetimibe and garlic extract, VI-Ezetimibe (30 microgram/kg) and VII-garlic extract (10 mg/kg).
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : 80% MethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Dose in 53 L**Duration : -Type of interaction : PharmacokineticsInteraction with drug : TrifluroperazineDose/Conc.(drug) : 60 micromolarResult : NegativeRemark : Results: data points did not fit the IC50 curve.Note : Type of experiment: *Human liver microsomal (HLM) **Working solutions were freshly prepared so that final herbal concentrations in screening incubations would represent the recommended daily intake of each extract in 53, 5.3, and 0.53 liters. Each herbal extract was coincubated at three concentrations with trifluoperazine (for UGT1A4), serotonin (for UGT1A6), and mycophenolic acid (for UGT1A9) and human liver microsome. Formation of trifluoperezine glucoronide, serotonin glucuronide, and mycophenolic acid beta-D- glucoronide were used as index reactions for activity of UGT1A4, UGT1A6, and UGT1A9 enzyme activities, respectively.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : 80% MethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Dose in 5.3 L**Duration : -Type of interaction : PharmacokineticsInteraction with drug : TrifluroperazineDose/Conc.(drug) : 60 micromolarResult : NegativeRemark : Results: data points did not fit the IC50 curve.Note : Type of experiment: *Human liver microsomal (HLM) **Working solutions were freshly prepared so that final herbal concentrations in screening incubations would represent the recommended daily intake of each extract in 53, 5.3, and 0.53 liters. Each herbal extract was coincubated at three concentrations with trifluoperazine (for UGT1A4), serotonin (for UGT1A6), and mycophenolic acid (for UGT1A9) and human liver microsome. Formation of trifluoperezine glucoronide, serotonin glucuronide, and mycophenolic acid beta-D- glucoronide were used as index reactions for activity of UGT1A4, UGT1A6, and UGT1A9 enzyme activities, respectively.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : 80% MethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Dose in 0.53 L**Duration : -Type of interaction : PharmacokineticsInteraction with drug : TrifluroperazineDose/Conc.(drug) : 60 micromolarResult : NegativeRemark : Results: data points did not fit the IC50 curve.Note : Type of experiment: *Human liver microsomal (HLM) **Working solutions were freshly prepared so that final herbal concentrations in screening incubations would represent the recommended daily intake of each extract in 53, 5.3, and 0.53 liters. Each herbal extract was coincubated at three concentrations with trifluoperazine (for UGT1A4), serotonin (for UGT1A6), and mycophenolic acid (for UGT1A9) and human liver microsome. Formation of trifluoperezine glucoronide, serotonin glucuronide, and mycophenolic acid beta-D- glucoronide were used as index reactions for activity of UGT1A4, UGT1A6, and UGT1A9 enzyme activities, respectively.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : 80% MethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Dose in 53 L**Duration : -Type of interaction : PharmacokineticsInteraction with drug : Serotonin*/5-hydroxytryptamine/5-HTDose/Conc.(drug) : 80 mMResult : NegativeRemark : Results: data points did not fit the IC50 curve.Note : Type of experiment: *Human liver microsomal (HLM) **Working solutions were freshly prepared so that final herbal concentrations in screening incubations would represent the recommended daily intake of each extract in 53, 5.3, and 0.53 liters. Each herbal extract was coincubated at three concentrations with trifluoperazine (for UGT1A4), serotonin (for UGT1A6), and mycophenolic acid (for UGT1A9) and human liver microsome. Formation of trifluoperezine glucoronide, serotonin glucuronide, and mycophenolic acid beta-D- glucoronide were used as index reactions for activity of UGT1A4, UGT1A6, and UGT1A9 enzyme activities, respectively.
