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| Thai / English name |
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 56 (M/F = 24/32)N(Treatment) : 1Sex : Both sexAge : 68.7 +/- 7.7 yrsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Hydrochlorothiazide*/HCTZDose/Conc.(drug) : -Result : PositiveRemark : กระเทียม/น้ำมันกระเทียมมีฤทธิ์ลดความดันโลหิต จึงอาจเสริมฤทธิ์กับยาที่มีฤทธิ์ลดความดันโลหิต ทำให้ความดันโลหิตต่ำลงได้Note : Data incomplete, data from review article
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 56 (M/F = 24/32)N(Treatment) : 1Sex : Both sexAge : 68.7 +/- 7.7 yrsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : SimvastatinDose/Conc.(drug) : -Result : PositiveRemark : กระเทียม/น้ำมันกระเทียมมีฤทธิ์เหนี่ยวนำเอนไซม์ CYP3A4 ทำให้ยาเมตาบอไลซ์ผ่านเอนไซม์ถูกแปรสภาพเพิ่มขึ้น ทำให้ระดับยาในเลือดลดลงNote : Data incomplete, data from review article
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 56 (M/F = 24/32)N(Treatment) : 2Sex : Both sexAge : 68.7 +/- 7.7 yrsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Aspirin*/Acetylsalicylic acid/ASA/EcosprinDose/Conc.(drug) : -Result : PositiveRemark : กระเทียม/น้ำมันกระเทียมมีฤทธิ์ยับยั้งการเกาะกลุ่มของเกล็ดเลือด จึงเสริมฤทธิ์ของ aspirin เพิ่มความเสี่ยงการเกิดภาวะเลือดออกNote : Data incomplete, data from review article
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : diallyl disulfideType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Cyclophosphamide*/CPM/CTX/CYTDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment = maternal liver and placentaNote : Diallyl disulfide (DADS) treatment significantly attenuated cyclophosphamide-induced developmental toxicity and oxidative damage in the maternal liver. DADS also significantly increased expression of CYP3A1 in the maternal liver placenta.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 25 microgram/mlDuration : 5 minutesType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : - Details of the standardized Garlic extracts: Garlic extract 100:1 (m/m), Allicin scordinin alliin.Note : The effects of complementary and alternative medicine (CAM) on CYP3A4-mediated metabolism of midazolam and docetaxel were determined in human liver microsomes (HLM), using liquid-chromatography coupled to tandem mass spectrometry (LC-MS/MS).
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 microgram/mlDuration : 30 minutesType of interaction : PharmacokineticsInteraction with drug : Docetaxel*/TaxotereDose/Conc.(drug) : -Result : PositiveRemark : - Details of the standardized Garlic extracts: Garlic extract 100:1 (m/m), Allicin scordinin alliin.Note : The effects of complementary and alternative medicine (CAM) on CYP3A4-mediated metabolism of midazolam and docetaxel were determined in human liver microsomes (HLM), using liquid-chromatography coupled to tandem mass spectrometry (LC-MS/MS).
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : Garlic extract (GE)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1.2 g/kg amikacin (AMK) was injected i.p., to rats as a single dose. Two dose of GE (300 mg) were given orally at the day of injgection and one day before injfection of AMK. The rats were sacrificed on the eighth day.Duration : 8 daysType of interaction : PharmacodynamicsInteraction with drug : AmikacinDose/Conc.(drug) : -Result : PositiveRemark : Result: GE significantly decreased the levels of nitric oxide, malondialdehyde and total antioxidant capacity. Furthermore, it increased the level of reduced glutathione. These changes are indicative for lower tissue damage and reduced free radical formation. These results were coinciding with the lower levels of urea, uric acid and creatinine (which were significantly elevated in amikacin treated groups). Semi-quantitative analysis of cellular infiltration, necrosis of tubular cells and tubular cellular damage indicated the protective effect of GE in reducing renal damage induced by amikacin.Note : By using a rat model, Nigella sativa oil and Allium sativum extract efficiently ameliorated the renal toxic effect of amikacin.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : SimvastatinDose/Conc.(drug) : -Result : PositiveRemark : Garlic was found to enhance the simvastatin activity in normalized lipidogram in experimental rasts.Note : Data from review
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : non specifiedType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : LisinoprilDose/Conc.(drug) : -Result : PositiveRemark : Reduction of CYP2E1 activity in humans and some animal species; no increase in CYP2B1/2 in humans. Mild inhibition of Pgp in vitro. Single reports of increased bleeding time with lisinopril, warfarin. Reduces bioavailability of the protease inhibitor saquinavir and to a lesser extent ritonavir. Appears safe with most drugs except saquinavir.Note : Data from review, data incomplete.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : non specifiedType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : Reduction of CYP2E1 activity in humans and some animal species; no increase in CYP2B1/2 in humans. Mild inhibition of Pgp in vitro. Single reports of increased bleeding time with lisinopril, warfarin. Reduces bioavailability of the protease inhibitor saquinavir and to a lesser extent ritonavir. Appears safe with most drugs except saquinavir.Note : Data from review, data incomplete.
