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| Thai / English name |
Part Used : น้ำมันActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12 (M/F=6/6)N(Treatment) : 12 (M/F=6/6)Sex : Both sexAge : 67+/-5.2 yrs.Route : Oral administrationDose/Conc.(herb) : 500 mg three times dailyDuration : 28 daysType of interaction : PharmacokineticsInteraction with drug : Debrisoquin*/Debrisoquine/Debrisochinum/IsocaramidineDose/Conc.(drug) : 5 mgResult : PositiveRemark :Note : Twelve healthy volunteers were randomly assigned to receive each botanical supplement for 28 days followed by a 30-day washout period. Probe drug cocktails of midazolam, caffeine, chlorzoxazone and debrisoquine were administered before (days -1, 0) and at the end of supplementation (days 27, 28). Pre- and post-supplementation phenotypic ratios were determined for CYP3A4, CYP1A2, CYP2E1 and CYP2D6 using 1-hydroxymidazolam/midazolam serum ratios (1-hour), paraxanthine/caffeine serum ratios (6-hour), 6-hydroxychlorzoxazone/chlorzoxazone serum ratios (2-hour) and debrisoquine urinary recovery ratios (8-hour), respectively.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : humanType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : LisinoprilDose/Conc.(drug) : -Result : PositiveRemark : Single reports of increased bleeding time with lisinopril, warfarin.Note : Data incomplete, data from review article.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : humanType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : Single reports of increased bleeding time with lisinopril, warfarin.Note : Data incomplete, data from review article.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 microgram/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark :
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : p-coumaric acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0-100 micromolarDuration : 24-48 hoursType of interaction : PharmacodynamicsInteraction with drug : Thiazolidinedione*/2,4-thiazolidinedioneDose/Conc.(drug) : 0-100 micromolarResult : PositiveRemark : - Thiazolidinedione (20 micromolar) in combination with ferulic acid (25 micromolar), eugenol (50 micromolar), chlorogenic acid (25 micromolar), caffeic acid (25 micromolar), and p-coumaric acid (25 micromolar) increased 2DG uptake by 7-, 6.8-, 6.7-, 6.5-, and 6.34-fold, respectively, with respect to control. - All of the phytochemicals, except cinnamic acid, showed synergistic behavior with both the OHDs in the uptake of 2DG, whereas cinnamic acid exhibited an additive effect.Note : The effect of cinnamic acid, ferulic acid, p-coumaric acid, eugenol, chlorogenic acid, and caffeic acid, alone and in combination with two commercial oral hypoglycemic drugs (OHD), namely, thiazolidinedione (THZ) and metformin on the uptake of 2-deoxyglucose (2DG) by 3T3-L1 adipocytes is studied.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : p-coumaric acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0-100 micromolarDuration : 24-48 hoursType of interaction : PharmacodynamicsInteraction with drug : MetforminDose/Conc.(drug) : 0-100 micromolarResult : PositiveRemark : - Metformin (20 micromolar) with ferulic acid (25 micromolar), eugenol (25 micromolar), chlorogenic acid (25 micromolar), p-coumaric acid (25 micromolar), caffeic acid (25 micromolar), and cinnamic acid (25 micromolar) increased 2DG uptake by 6.5-, 6.4-, 6.2-, 6.1-, 6.3-, and 5.9-fold, respectively, when compared to control. - All of the phytochemicals, except cinnamic acid, showed synergistic behavior with both the OHDs in the uptake of 2DG, whereas cinnamic acid exhibited an additive effect.Note : The effect of cinnamic acid, ferulic acid, p-coumaric acid, eugenol, chlorogenic acid, and caffeic acid, alone and in combination with two commercial oral hypoglycemic drugs (OHD), namely, thiazolidinedione (THZ) and metformin on the uptake of 2-deoxyglucose (2DG) by 3T3-L1 adipocytes is studied.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 18N(Treatment) : 18Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : allicin capsule 180 mg once dailyDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : OmeprazoleDose/Conc.(drug) : -Result : PositiveRemark : The results of this study demonstrate that allicin reduces the metabolism of omeprazole by inhibiting CYP2C19 activity in healthy Chinese male subjects with the genotype CYP2C19*1/CYP2C19*1 or CYP2C19*1/CYP2C19*2 or*3 but not CYP2C19*2/CYP2C19*2. Allicin did not significantly affect the activity of CYP3A4 in all subjects after 14 days of exposure.Note : - Eighteen subjects (six CYP2C19*1/CYP2C19*1, four CYP2C19*1/CYP2C19*2, two CYP2C19*1/CYP2C19*3, and six CYP2C19*2/CYP2C19*2) - On the 15th day, all subjects were given a single oral dose of omeprazole (20 mg capsule) with 250 ml of warm water after an overnight fast.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 56 (M/F = 24/32)N(Treatment) : 3Sex : Both sexAge : 68.7 +/- 7.7 yrsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Enalapril*/EnalaprilatDose/Conc.(drug) : -Result : PositiveRemark : กระเทียม/น้ำมันกระเทียมมีฤทธิ์ลดความดันโลหิต จึงอาจเสริมฤทธิ์กับยาที่มีฤทธิ์ลดความดันโลหิต ทำให้ความดันโลหิตต่ำลงได้Note : Data incomplete, data from review article
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 56 (M/F = 24/32)N(Treatment) : 3Sex : Both sexAge : 68.7 +/- 7.7 yrsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Amlodipine*/AmlopineDose/Conc.(drug) : -Result : PositiveRemark : กระเทียม/น้ำมันกระเทียมมีฤทธิ์ลดความดันโลหิต จึงอาจเสริมฤทธิ์กับยาที่มีฤทธิ์ลดความดันโลหิต ทำให้ความดันโลหิตต่ำลงได้Note : Data incomplete, data from review article
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 56 (M/F = 24/32)N(Treatment) : 1Sex : Both sexAge : 68.7 +/- 7.7 yrsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Isosorbide mononitrate*/ISMN/Isosorbide 5-mononitrate/MonosorbitrateDose/Conc.(drug) : -Result : PositiveRemark : กระเทียม/น้ำมันกระเทียมมีฤทธิ์ลดความดันโลหิต จึงอาจเสริมฤทธิ์กับยาที่มีฤทธิ์ลดความดันโลหิต ทำให้ความดันโลหิตต่ำลงได้Note : Data incomplete, data from review article
