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AMARYLLIDACEAE Allium sativum L.

Synonym

none ...

Thai / English name

กระเทียม*

[8-9] of 9 article(s) found

หน้า 1 2

[8] DRUG INTERACTIONS WITH GARLIC AND GINGER SUPPLEMENTS.
ABOU-DIWAN,CHARBEL;RITCHIE,JAMES.
HERBAL SUPPLEMENTS 2011 Vol.(),333-50 $60025 [Full]

Part Used : หัว
Activity : CYP3A4 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Garlic constituents have been shown to modulate the activity of various CYP isozymes in vitro. These constituents exhibit and inhibitory effect on CYP2C9* 1, CYP2C19, CYP3A4, CYP3A5, and CYP3A7 metabolism, whereas no effect on CYP2D6 was observed.

Note : Data incomplete, data from review article

Part Used : หัว
Activity : CYP3A4 INHIBITION

Solvent/Active Compound : garlic oil

Type of experiment : human
Type of animal : -

Type of study : non specified

N(Total) : 12
N(Treatment) : 12

Sex : -
Age : 60-76 yrs

Route : Oral administration
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Midazolam*/Versed/Dormicum
Dose/Conc.(drug) : -

Result : Negative

Remark : The study using midazolam as a probe, similarly reported that supplementation with garlic oil did not alter the activity of CYP3A4 in 12 healthy volunteers.

Note : Data incomplete, data from review article

Part Used : หัว
Activity : CYP3A4 INHIBITION

Solvent/Active Compound : fresh and aged garlic extract

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Garlic extracts, both fresh and aged, were responsible for the inhibition of CYP3A4 in human liver microsomes, and complementary DNA (cDNA) - expressed CYP2C9, CYP2C19, CYP3A4, CYP3A5, and CYP3A7 activities.

Note : Data incomplete, data from review article

[9] INHIBITING ACTIVITY OF GARLIC ON A DRUG METABOLIZING ENZYME CYP3A4.
CHA BC,LEE EH
SAENGYAK HAKHOECHI 2006 Vol.37(2),97-102 339909 [Abstract]

Part Used : -
Activity : CYP3A4 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : non specified

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : EtOAc exts. of garlic, we found that N-p-coumaroyltyramine and N-feruloyltyramine showed remarkable CYP3A4-inhibiting activities, compared to diallyl disulfide.

Note : Data incomplete from abstract

หน้า 1 2

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