Part Used : หัว
Activity : TUMOR PROMOTION INHIBITION
Solvent/Active Compound : aged garlic extract (AGE)
Type of experiment : in vivo
Type of animal : mouse
N(Total) : -
N(Treatment) : -
Route : Intraperitoneal
Dose/Conc.(herb) : AGE 100 mg/kg
Duration : -
Type of interaction : P.Kinetics & P.Dynamics
Interaction with drug : Naltrexone
Dose/Conc.(drug) : 0.5 mg/kg, i.p.
Remark : Results: The mice who received AGE+NTX had significantly longer survival time compared with the mice treated with AGE or NTX alone. An enhanced inhibitory effect on tumor growth was seen in combination therapy group. The CD4+/CD8+ ratio and in vitro lFN-gamma production of splenocytes were significantly increased in AGE+NTX and NTX groups. WEHl-164 spectific cytotoxicity of splenocytes was also significantly increased at 25:1 E:T ratio in AGE+NTX treated mice. Coadministration of AGE with NTX resulted in improvement of immune responses against experimentally implanted fibrosarcoma tumors in BALB/c mice.
Note : Type of experiment: BALB/c mice at 6-8 weeks of age went under experimental induction of tumor by injection of WEHl-164 cells. Tumorized mice were randomly divided into 4 groups, the first group received aged garlic extract (AGE), the second group received naltrexone (NTX), the third group received both of them, and the fourth group (the control or PBS group) received only phosphated buffered saline (PBS).
