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| Thai / English name |
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : non specifiedType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : RitonavirDose/Conc.(drug) : -Result : PositiveRemark : Reduction of CYP2E1 activity in humans and some animal species; no increase in CYP2B1/2 in humans. Mild inhibition of Pgp in vitro. Single reports of increased bleeding time with lisinopril, warfarin. Reduces bioavailability of the protease inhibitor saquinavir and to a lesser extent ritonavir. Appears safe with most drugs except saquinavir.Note : Data from review, data incomplete.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 10 (M/F=5/5)N(Treatment) : 10Sex : Both sexAge : -Route : Oral administrationDose/Conc.(herb) : 2 garlic capsules (10 mg of odorless garlic extract)Duration : 4 daysType of interaction : PharmacokineticsInteraction with drug : RitonavirDose/Conc.(drug) : 400 mg, single doseResult : NegativeRemark : In a trial of the HIV - 1 protease inhibitor ritonavir, the administration of two garlic capsules (10 mg of natural source odorless garlic extract) for 4 days in healthy volunteers did not significantly alter its single - dose pharmacokinetics.Note : Data incomplete, data from review article
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case reportN(Total) : 2N(Treatment) : 2Sex : Both sexAge : -Route : Oral administrationDose/Conc.(herb) : -Duration : > 2 weeksType of interaction : PharmacokineticsInteraction with drug : RitonavirDose/Conc.(drug) : 100 mg twice dailyResult : PositiveRemark : A two HIV - infected patients taking garlic supplements for > 2 weeks reveals the development of severe gastrointestinal toxicity after the initiation of ritonavir - containing antiretroviral therapy (400 or 600 mg twice daily). Moreover, these symptoms resolved after discontinuing garlic or ritonavir. This occurrence was not likely related to increased systemic concentrations of ritonavir. In addition, gastrointestinal symptoms recurred during rechallenge with low - dose ritonavir (100 mg twice daily) in the presence of garlic.Note : Data incomplete, data from review article
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case reportN(Total) : 2N(Treatment) : 2Sex : Both sexAge : -Route : Oral administrationDose/Conc.(herb) : -Duration : > 2 weeksType of interaction : PharmacokineticsInteraction with drug : RitonavirDose/Conc.(drug) : 400 mg twice dailyResult : PositiveRemark : A two HIV - infected patients taking garlic supplements for > 2 weeks reveals the development of severe gastrointestinal toxicity after the initiation of ritonavir - containing antiretroviral therapy (400 or 600 mg twice daily). Moreover, these symptoms resolved after discontinuing garlic or ritonavir. This occurrence was not likely related to increased systemic concentrations of ritonavir. In addition, gastrointestinal symptoms recurred during rechallenge with low - dose ritonavir (100 mg twice daily) in the presence of garlic.Note : Data incomplete, data from review article
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case reportN(Total) : 2N(Treatment) : 2Sex : Both sexAge : -Route : Oral administrationDose/Conc.(herb) : -Duration : > 2 weeksType of interaction : PharmacokineticsInteraction with drug : RitonavirDose/Conc.(drug) : 600 mg twice dailyResult : PositiveRemark : A two HIV - infected patients taking garlic supplements for > 2 weeks reveals the development of severe gastrointestinal toxicity after the initiation of ritonavir - containing antiretroviral therapy (400 or 600 mg twice daily). Moreover, these symptoms resolved after discontinuing garlic or ritonavir. This occurrence was not likely related to increased systemic concentrations of ritonavir. In addition, gastrointestinal symptoms recurred during rechallenge with low - dose ritonavir (100 mg twice daily) in the presence of garlic.Note : Data incomplete, data from review article
